Abstract
This article provides a comprehensive overview of 4-Fluoro-3-Nitroaniline, CAS 364-76-1, from a user’s perspective. It delves into the chemical properties, synthesis methods, applications, safety considerations, storage, and handling of this compound. By exploring these aspects, the article aims to offer valuable insights for researchers, chemists, and anyone interested in understanding the nuances of 4-Fluoro-3-Nitroaniline.
Introduction to 4-Fluoro-3-Nitroaniline CAS 364-76-1
4-Fluoro-3-Nitroaniline, with the chemical formula C6H4FNO2, is a synthetic organic compound that has gained significant attention in various scientific fields. It is a derivative of aniline, characterized by the presence of a fluorine atom and a nitro group at the 3rd and 4th positions of the benzene ring, respectively. This compound is widely used in the synthesis of dyes, pharmaceuticals, and agrochemicals. In this article, we will explore the must-know facts about 4-Fluoro-3-Nitroaniline CAS 364-76-1, providing a user’s perspective on its properties and applications.
Chemical Properties
4-Fluoro-3-Nitroaniline is a crystalline solid that is soluble in organic solvents such as acetone, ethanol, and dimethylformamide. It has a melting point of approximately 178-180°C and a boiling point of around 312°C. The compound is yellowish in color and emits a pungent odor. Its molecular weight is 165.12 g/mol, and it has a molecular formula of C6H4FNO2. The presence of the nitro group makes it a strong oxidizing agent, which can be hazardous during handling and storage.
Synthesis Methods
The synthesis of 4-Fluoro-3-Nitroaniline can be achieved through various methods, including the nitration of 3-fluoroaniline and the nitration of aniline followed by fluorination. The nitration of 3-fluoroaniline involves the reaction of 3-fluoroaniline with a mixture of nitric acid and sulfuric acid, which leads to the formation of 4-nitro-3-fluoroaniline. The nitration of aniline followed by fluorination involves the nitration of aniline to form 3-nitroaniline, which is then fluorinated to yield 4-Fluoro-3-Nitroaniline. These methods require careful control of reaction conditions to ensure the desired product is obtained.
Applications
4-Fluoro-3-Nitroaniline finds extensive applications in the synthesis of dyes, pharmaceuticals, and agrochemicals. It is used as an intermediate in the production of dyes, particularly in the textile industry. In the pharmaceutical sector, it serves as a precursor for the synthesis of various drugs, including anti-inflammatory agents and analgesics. Additionally, it is employed in the agrochemical industry for the development of herbicides and insecticides.
Safety Considerations
Handling 4-Fluoro-3-Nitroaniline requires strict adherence to safety protocols due to its oxidizing nature and potential health hazards. It is essential to wear appropriate personal protective equipment, such as gloves, goggles, and lab coats, when working with this compound. In case of accidental exposure, immediate washing with plenty of water and seeking medical attention is recommended. Storage of 4-Fluoro-3-Nitroaniline should be in a cool, dry place, away from incompatible materials and sources of ignition.
Storage and Handling
Proper storage and handling of 4-Fluoro-3-Nitroaniline are crucial to ensure safety and maintain the integrity of the compound. It should be stored in a tightly sealed container, away from direct sunlight and heat. Incompatible materials, such as strong reducing agents and organic metals, should be kept away from 4-Fluoro-3-Nitroaniline to prevent hazardous reactions. During handling, it is essential to avoid contact with skin and eyes, and proper ventilation should be maintained in the laboratory to prevent inhalation of dust or vapors.
Conclusion
In conclusion, 4-Fluoro-3-Nitroaniline CAS 364-76-1 is a versatile organic compound with a wide range of applications in various industries. Understanding its chemical properties, synthesis methods, applications, safety considerations, storage, and handling is essential for researchers, chemists, and users of this compound. By adhering to the guidelines outlined in this article, users can ensure the safe and effective utilization of 4-Fluoro-3-Nitroaniline in their respective fields.
Keywords: 4-Fluoro-3-Nitroaniline, CAS 364-76-1, chemical properties, synthesis methods, applications, safety considerations, storage, handling
