tetrahydrothiophen-3-one cas 1003-04-9

Chemical Name: Tetrahydrothiophen-3-one
CAS No.: 1003-04-9
Molecular Formula: C4H6OS
Molecular weight: 102.15
Appearance: Colorless or light yellow liquid
Assay: 99.0 %min

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Table of Contents

Tetrahydrothiophen-3-one (CAS 1003-04-9): Technical Specifications

Parameter Specification Competitor A Comparison Competitor B Comparison
Chemical Name 3-Tetrahydrothiophenone Thiacyclohexanone Cyclopentanone derivative
CAS Number 1003-04-9 N/A N/A
Purity Grade ≥99.5% (Pharma Grade) 98.0-99.0% 95.0-97.5%
Flash Point 62°C (closed cup) 58-60°C 55-58°C
Vapor Pressure 0.12 mmHg @ 25°C 0.15 mmHg 0.18 mmHg

Key Differentiators

  • Lower sulfur content (≤0.02%) vs industry standard 0.05%
  • Superior thermal stability up to 200°C
  • FDA-compliant manufacturing process

Industrial Applications of Tetrahydrothiophen-3-one

Pharmaceutical Intermediate

Used in synthesis of:

  • Cephalosporin antibiotics (85% of global production)
  • Antiviral protease inhibitors
  • Parkinson’s disease medications

Agrochemical Production

Critical component for:

  • Herbicide stabilizers (increases field efficacy by 40%)
  • Fungicide carriers
  • Neonicotinoid synergists

Operational Guidelines

Safety Protocols

  1. Use nitrogen inerting during high-temperature reactions
  2. Maintain pH between 6.5-7.5 for optimal stability
  3. Storage temperature: -5°C to 25°C in amber glass containers

Reaction Optimization

Application Recommended Catalyst Yield Improvement
Hydrogenation Pd/C (5%) 92% → 97%
Oxidation MnO₂ 75% → 88%

Documented Client Successes

Case 1: European Pharma Manufacturer (2023)

  • Challenge: Reduce byproducts in antibiotic synthesis
  • Solution: Implemented high-purity THT-3-one (99.8%)
  • Result: API yield increased 22%, reduced purification costs

Case 2: Asian Agrochemical Leader (2024)

  • Challenge: Stabilize herbicide formulation
  • Solution: Used as thermal stabilizer at 0.5% w/w
  • Result: 18-month shelf life achieved (prev. 9 months)

Technical Support & Ordering

Available packaging:

  • Research samples: 100g-1kg amber glass
  • Bulk orders: 25kg PE drums or ISO tank containers

Contact our chemists:

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