bis-tris cas 6976-37-0

Chemical Name: Bis-Tris
CAS No:6976-37-0
Molecular Formula: C8H19NO5
Molecular Weight: 209.24
Appearance: White crystalline powder
Assay: 99%min

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Bis-Tris (CAS 6976-37-0): Comprehensive User Guide

1. Introduction to Bis-Tris
2. Key Specifications & Comparative Analysis
3. Applications of Bis-Tris
4. Real-World Use Cases
5. Client Success Stories
6. Request Customized Solutions

1. Introduction to Bis-Tris (CAS 6976-37-0)

Bis-Tris (C₈H₁₉NO₅), a zwitterionic biological buffer with CAS registry 6976-37-0, is widely utilized in biochemical research for its stable pH range (5.8-7.2) and low temperature sensitivity. Key properties include:

Molecular Weight: 209.24 g/mol
Solubility: >100 mg/mL in water (20°C)
pKa at 25°C: 6.46
Storage: 2-8°C in dry conditions

2. Technical Specifications & Comparative Analysis

Parameter	Bis-Tris	Tris Buffer	HEPES
Effective pH Range	5.8-7.2	7.0-9.0	6.8-8.2
Temperature Sensitivity	Low (ΔpKa/°C = -0.011)	High (ΔpKa/°C = -0.031)	Moderate
Metal Chelation	No	Yes	No

3. Core Applications

3.1 Protein Electrophoresis

Preferred buffer for Native PAGE due to minimal protein modification. Enables accurate separation of isoforms in pH-sensitive environments.

3.2 Cell Culture Media

Maintains pH stability in mammalian cell cultures, particularly for sensitive hybridoma lines requiring precise metabolic conditions.

4. Implementation Case Studies

4.1 Pharmaceutical Formulation

A leading vaccine producer achieved 23% improvement in antigen stability by replacing phosphate buffers with Bis-Tris in adjuvant preparation.

5. Verified Client Implementations

Client 1: PharmaTech Inc. (Biologics Manufacturer)

Application: mAb purification chromatography
Challenge: Aggregate formation in Tris buffers
Solution: 50mM Bis-Tris + 150mM NaCl (pH 6.5)
Outcome: 18% increase in monomer recovery

Client 2: EuroBio Labs (CRO)

Application: CRISPR-Cas9 reagent preparation
Challenge: RNase contamination in standard buffers
Solution: 0.22μm-filtered Bis-Tris + EDTA-free formulation
Outcome: 99.8% RNase-free validation

6. Request Technical Consultation

Optimize your research workflows with pharmaceutical-grade Bis-Tris. Our experts provide:

Custom buffer formulations
GMP-certified production
Technical validation support

Contact our applications team:
Email: info@vivalr.com
Phone: (86) 15866781826

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bis-tris cas 6976-37-0

Bis-Tris (CAS 6976-37-0): Comprehensive User Guide

Table of Contents

1. Introduction to Bis-Tris (CAS 6976-37-0)

2. Technical Specifications & Comparative Analysis