L-Glutamic Acid Hydrochloride (CAS 138-15-8): Technical Guide & Applications
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| CAS No. | 138-15-8 |
| Molecular Formula | C5H10ClNO4 |
| Molecular Weight | 183.59 g/mol |
| Purity | ≥99% (BR grade) |
| Appearance | White crystalline powder |
| Melting Point | 202–214°C (decomposition) |
| Specific Rotation | +23.5° to +25.5° (c=10, 2N HCl) |
| Solubility | 1 g dissolves in 3 mL water; insoluble in ethanol/ether |
| Storage | Room temperature, 2-year shelf life |
2. Key Applications
Biomedical Research
Acts as an agonist for kainate, NMDA, and quisqualate receptors, making it critical in neuroscience studies of excitatory neurotransmission.
Food Industry
Used as a flavor enhancer, salt substitute, and nutritional additive due to its umami properties.
Pharmaceuticals
Serves as an intermediate in drug synthesis and diagnostic reagent formulations.
3. Performance Characteristics
- Stability: Complies with NCCLS EP5-A standards under accelerated thermal testing.
- Sensitivity: High reactivity in receptor-binding assays (ΔA/μM ≥0.15).
- Linearity: Validated range of 0.1–10 mM (R² >0.99).
- Matrix Effects: ≤5% interference in biological samples.
4. Case Studies
Case 1: Neuropharmacology Research
A leading university utilized L-glutamic acid HCl to study glutamate receptor modulation in neurodegenerative diseases, achieving 95% assay reproducibility.
Case 2: Food Additive Development
A food manufacturer incorporated this compound into low-sodium products, reducing NaCl content by 40% while maintaining palatability.
5. Safety & Handling
- Hazard Code: R41 (Risk of serious eye irritation)
- Precautionary Measures: Use PPE (gloves, goggles).
- First Aid: Flush eyes with water for 15 minutes if exposed.
6. Request a Quotation
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