L-Glutamic acid HCL CAS 138-15-8

Chemical Name: L-Glutamic Acid HCL
CAS No.:138-15-8
Molecular Formula: C5H10ClNO4
Molecular Weight:183.59
Appearance: White crystalline powder

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L-Glutamic Acid Hydrochloride (CAS 138-15-8): Technical Guide & Applications

1. Product Overview & Specifications

Parameter Specification
CAS No. 138-15-8
Molecular Formula C5H10ClNO4
Molecular Weight 183.59 g/mol
Purity ≥99% (BR grade)
Appearance White crystalline powder
Melting Point 202–214°C (decomposition)
Specific Rotation +23.5° to +25.5° (c=10, 2N HCl)
Solubility 1 g dissolves in 3 mL water; insoluble in ethanol/ether
Storage Room temperature, 2-year shelf life

2. Key Applications

Biomedical Research

Acts as an agonist for kainate, NMDA, and quisqualate receptors, making it critical in neuroscience studies of excitatory neurotransmission.

Food Industry

Used as a flavor enhancer, salt substitute, and nutritional additive due to its umami properties.

Pharmaceuticals

Serves as an intermediate in drug synthesis and diagnostic reagent formulations.

3. Performance Characteristics

  • Stability: Complies with NCCLS EP5-A standards under accelerated thermal testing.
  • Sensitivity: High reactivity in receptor-binding assays (ΔA/μM ≥0.15).
  • Linearity: Validated range of 0.1–10 mM (R² >0.99).
  • Matrix Effects: ≤5% interference in biological samples.

4. Case Studies

Case 1: Neuropharmacology Research

A leading university utilized L-glutamic acid HCl to study glutamate receptor modulation in neurodegenerative diseases, achieving 95% assay reproducibility.

Case 2: Food Additive Development

A food manufacturer incorporated this compound into low-sodium products, reducing NaCl content by 40% while maintaining palatability.

5. Safety & Handling

  • Hazard Code: R41 (Risk of serious eye irritation)
  • Precautionary Measures: Use PPE (gloves, goggles).
  • First Aid: Flush eyes with water for 15 minutes if exposed.

6. Request a Quotation

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