1. Product Overview & Specifications

Key Advantages: Higher thermal stability vs. chloro derivatives, optimal reactivity for coupling reactions, and reduced toxicity compared to iodo analogs.

2. Key Applications

Pharmaceutical Intermediates

Critical precursor for:

• Anticancer drug candidates (e.g., kinase inhibitors)
• Antidepressant synthesis
• Non-steroidal anti-inflammatory agents

Agrochemical Production

• Herbicide metabolites
• Fungicidal additives
• Plant growth regulator intermediates

Material Science

• Liquid crystal precursors
• Conductive polymer dopants
• OLED material synthesis

3. Usage Guidelines

Handling Protocols

• Store at 2-8°C in amber glass under nitrogen
• Use PPE: neoprene gloves, chemical goggles
• Incompatible with strong oxidizers

Synthetic Procedures

Buchwald-Hartwig Amination Example:
1. Mix 4-bromoaniline (1 eq) with aryl halide (1.2 eq)
2. Add Pd(OAc)₂ (5 mol%), XPhos (10 mol%)
3. React in dioxane at 100°C for 12h
4. Isolate via column chromatography (Hex:EA = 3:1)

4. Industry Case Studies

Case 1: PharmaGen Solutions

Challenge: Scale-up of tyrosine kinase inhibitor intermediate
Solution: Optimized Ullmann coupling using 4-bromoaniline
Result: 92% yield at 500kg batch scale

Case 2: AgroShield Ltd

Challenge: Develop persistent fungicidal metabolite
Solution: Directed bromination pattern using 4-bromoaniline derivatives
Result: 68% improved field persistence vs. chlorinated analogs

5. Request Custom Solutions

Contact our technical team for:

• Bulk pricing (100kg+ orders)
• Custom synthesis (purity 99.5%+ available)
• Regulatory support (REACH, TSCA compliant)

Email: info@vivalr.com
Tel: (86) 15866781826