Pyrazine

Product Name:Pyrazine
CAS:290-37-9
MFC4H4N2
MW:80.09
EINECS:206-027-6
MOL File:290-37-9.mol

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Pyrazine (CAS 290-37-9): Comprehensive Technical Guide

1. Technical Specifications & Comparative Analysis

Parameter Pyrazine Pyrimidine Pyridazine
CAS Number 290-37-9 289-95-2 289-80-5
Molecular Formula C4H4N2 C4H4N2 C4H4N2
Melting Point 54°C 20-22°C -8°C
Boiling Point 115-116°C 123-124°C 208°C
Aromaticity Index 0.68 0.72 0.65

2. Industrial Applications

Core Functional Uses:

  • Pharmaceutical intermediates for antitubercular drugs (e.g., Pyrazinamide)
  • Flavor enhancer in food industry (GRAS status)
  • Key precursor in agrochemical synthesis
  • Electron-deficient scaffold in OLED materials
  • Coordination ligand in catalytic systems

Material Compatibility:

  • Solubility: Water (10 g/100ml), Ethanol (∞), Chloroform (∞)
  • Storage: Nitrogen atmosphere, <25°C
  • Incompatible Materials: Strong oxidizers, mineral acids

3. Operational Guidelines

Process Optimization:

  • Reaction Vessels: Glass-lined or Hastelloy C-276
  • Temperature Control: ±1°C tolerance required
  • Purification Methods: Vacuum distillation (≤5mmHg)

Safety Protocols:

  • PPE Requirements: Chem-resistant gloves (≥8mil), Full-face shield
  • Exposure Limits: TWA 2 mg/m³ (ACGIH)
  • Spill Management: Vermiculite absorption, pH neutralization

4. Industrial Case Studies

Case 1: Pharmaceutical Intermediate Production

Client: Jiangxi Jianglan Pure Bio-Chem Co., Ltd.
Application: Pyrazinamide API synthesis
Outcome: Achieved 99.7% purity (HPLC), 22% yield improvement

Case 2: Specialty Flavor Development

Client: Shenzhen Hisunt Pharmaceutical Co., Ltd.
Application: Acetylpyrazine synthesis for savory flavors
Outcome: 15% cost reduction vs traditional methods

5. Technical Consultation

For customized formulations or technical specifications:
Email: info@vivalr.com
Tel: (86) 15866781826

Quality Assurance:

  • Certifications: ISO 9001:2025, REACH compliant
  • Batch Consistency: ±0.5% purity variance
  • Lead Time: 3-5 business days (standard orders)

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