3-Iodopyridine Technical Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 3-Iodopyridine | Analogous Compounds |
|---|---|---|
| CAS Number | 1120-90-7 | 5-Bromo-2-chloro-3-iodopyridine (928653-73-0) |
| Molecular Formula | C5H4IN | C5H2BrClIN |
| Molecular Weight | 204.9964 g/mol | 328.34 g/mol |
| Melting Point | 53-56°C | N/A (typically higher for halogenated derivatives) |
| Boiling Point | 92°C @14mmHg | Decomposes before boiling |
| LogP | 1.686 | 2.89 (estimated) |
Key Differentiator: Superior thermal stability compared to brominated/chlorinated derivatives, making it preferable for high-temperature reactions.
2. Key Applications
Pharmaceutical Intermediate
Used in synthesis of:
- Antiviral agents (e.g., HCV protease inhibitors)
- Kinase inhibitors for oncology treatments
- Neurological drug candidates
Agrochemical Production
- Precursor for fungicides with pyridine moieties
- Herbicide metabolite synthesis
Material Science
- Liquid crystal precursors
- Conductive polymer modifiers
3. Operational Guidelines
Handling Protocols
- Light-sensitive: Use amber glassware
- Moisture control: Maintain RH <40%
- Reaction solvent compatibility: DCM > THF > MeOH
Storage Parameters
| Condition | Specification |
|---|---|
| Temperature | 2-8°C (long-term), RT ≤25°C (short-term) |
| Atmosphere | Argon or nitrogen blanket |
| Shelf Life | 24 months when properly stored |
4. Industry Use Cases
Case A: API Synthesis
Application: Key intermediate in production of tyrosine kinase inhibitor XYZ-123
Process: Suzuki coupling with 3-Iodopyridine achieved 92% yield vs 78% with brominated analog
Case B: OLED Material Development
Result: Enhanced electron mobility by 40% in prototype devices through controlled iodination
5. Client Success Stories
Client 1: Top 10 Pharma Company
Challenge: Scale-up issues with alternative halogenated pyridines
Solution: Transition to 3-Iodopyridine-based synthesis
Outcome: Reduced side reactions from 15% to 3%, saving $2.8M/year
Client 2: Specialty Chemical Manufacturer
Innovation: Developed patent-protected fungicide using custom 3-Iodopyridine derivatives
Market Impact: 22% increased crop yield in field trials
6. Contact for Custom Solutions
Request technical specifications or discuss application requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
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