5-Bromo-6-Hydroxynicotinic Acid: Technical Guide & Procurement Insights
Table of Contents
- Product Overview & Specifications
- Key Applications in Industrial & Research Settings
- Handling & Usage Guidelines
- Industry Case Studies (Pharmaceuticals, Agrochemicals, Academia)
- Supplier Comparison (Purity, Packaging, Pricing)
- Request Custom Quotes & Technical Support
Product Overview & Specifications
Chemical Name: 5-Bromo-6-Hydroxynicotinic Acid
CAS Number: 913835-47-5
Molecular Formula: C6H4BrNO3
Molecular Weight: 218.01 g/mol
| Parameter | Specification |
|---|---|
| Appearance | Off-white to pale yellow crystalline powder |
| Purity (HPLC) | ≥98% |
| Melting Point | 248-252°C (dec.) |
| Solubility | Soluble in DMSO, methanol; slightly soluble in water |
| Storage | 2-8°C in airtight container |
Key Applications
Pharmaceutical Intermediate
Critical building block for kinase inhibitors and antiviral agents. Enables precise bromine substitution for targeted drug design.
Agrochemical Synthesis
Used in development of herbicidal compounds through selective functionalization of nicotinic acid derivatives.
Coordination Chemistry
Acts as polydentate ligand for transition metal catalysts in cross-coupling reactions.
Handling & Usage
| Aspect | Recommendation |
|---|---|
| Storage | Desiccate at 2-8°C; argon atmosphere for long-term storage |
| Handling | Use nitrile gloves and chemical goggles in fume hood |
| Solubility Optimization | Use DMSO for stock solutions (up to 50 mM) |
| Reaction Conditions | pH 6-8 aqueous environments; avoid strong oxidizers |
Industry Case Studies
Case 1: Oncology Drug Development
Client: Top 10 Global Pharma Company
Application: Synthesizing FGFR kinase inhibitor candidates
Result: Achieved 92% yield in key bromination step using our ≥99% purity material
Case 2: Next-Gen Herbicides
Client: European Agrochemical Leader
Application: Developing soil-stable nicotinic acid derivatives
Result: Reduced impurity levels by 40% compared to previous suppliers
Supplier Analysis
| Supplier | Purity | Packaging | Price (USD/g) |
|---|---|---|---|
| Vivalr Chemicals | 98-99% | 1g, 5g, 25g sealed ampules | $85-$220 |
| Sigma-Aldrich | 97% | 250mg increments | $120-$300 |
| TCI Chemicals | 95% | 1g minimum | $95-$250 |
Request Custom Quotes
Contact our technical team for:
– Bulk pricing (100g+)
– Regulatory documentation (CoA, MSDS)
– Custom synthesis services
Email: info@vivalr.com
Phone: (86) 15866781826
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