2-Hydroxypyridine: Technical Guide for Industrial Applications
Table of Contents
1. Chemical Profile & Specifications
| Parameter | Specification |
|---|---|
| Chemical Formula | C5H5NO |
| CAS Number | 142-08-5 |
| Molecular Weight | 95.10 g/mol |
| Appearance | White to pale yellow crystalline solid |
| Melting Point | 105-107°C |
| Boiling Point | 280-281°C |
| Solubility | Water: High Ethanol: Soluble Benzene/Ether: Slight |
| Density | 1.39 g/cm3 |
2. Key Applications
Pharmaceutical Synthesis
• Intermediate in nucleoside analog production (e.g., uridine/guanosine derivatives)
• Protecting group for imide functionalities in RNA/DNA research
Chemical Manufacturing
• Precursor for N-methylpyridone synthesis
• Building block for 2-methoxypyridine derivatives
• Bromination reactions to produce 3,5-dibromo-2-hydroxypyridine
Material Science
• Hydrogen-bonding component in supramolecular systems
• Chelating agent in coordination chemistry
3. Industrial Use Cases
Case 1: Nucleoside Protection
In antiviral drug development, 2-hydroxypyridine serves as a transient protective group during nucleotide modification processes, enabling precise control over glycosidic bond formation.
Case 2: Specialty Polymer Synthesis
Used as a chain-terminating agent in polyamide production, creating thermally stable polymers with enhanced solubility characteristics.
4. Client Success Stories
PharmaCorp Ltd.
Challenge: Required high-purity (>99.8%) 2-hydroxypyridine for mRNA vaccine adjuvant research.
Solution: Customized crystallization protocol achieving 99.92% purity.
Outcome: Enabled successful Phase II clinical trials with improved stability profiles.
ChemTech Industries
Challenge: Needed bulk quantities (500kg/month) for OLED precursor synthesis.
Solution: Scalable production with strict particle size distribution control.
Outcome: Reduced production costs by 18% while maintaining 99.5% batch consistency.
5. Contact for Custom Solutions
Request technical specifications, MSDS, or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826


评论
目前还没有评论。