5-Amino-2-Chloropyridine-4-Carboxylic Acid: Comprehensive Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Industry Use Cases
- 3. Performance Comparison with Alternatives
- 4. Operational Guidelines & Best Practices
- 5. Real-World Client Success Stories
- 6. Request Customized Technical Support
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| Chemical Formula | C6H5ClN2O2 |
| Molecular Weight | 172.57 g/mol |
| CAS Number | 1003749-44-7 |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity (HPLC) | ≥98% |
| Solubility | Soluble in DMSO, methanol; slightly soluble in water |
2. Key Applications & Industry Use Cases
Pharmaceutical Intermediates
Critical building block for:
- Kinase inhibitor development (EGFR, ALK)
- Anticancer drug candidates
- Antiviral compound synthesis
Agrochemical Applications
- Herbicide intermediates
- Fungicide molecular frameworks
- Plant growth regulator synthesis
3. Performance Comparison with Alternatives
| Compound | Reactivity | Thermal Stability | Synthetic Yield |
|---|---|---|---|
| 5-Amino-2-Cl-Pyridine-4-COOH | High | Excellent | 85-92% |
| 2-Chloro-4-pyridinecarboxylic acid | Moderate | Good | 70-78% |
4. Operational Guidelines & Best Practices
Storage Recommendations
- Store at 2-8°C in original packaging
- Protect from light and moisture
- Maximum shelf life: 24 months
Reaction Optimization
- Optimal coupling conditions: DMF solvent at 80°C
- Recommended catalyst: Pd(PPh3)4
- Ideal pH range: 6.5-7.5
5. Real-World Client Success Stories
Case Study 1: Oncology Drug Development
Client: PharmaCorp (Top 10 Global Pharma)
- Application: Third-generation EGFR inhibitor synthesis
- Result: Achieved 89% yield in key amidation step
- Scale: 150kg batch production
Case Study 2: Crop Protection Innovation
Client: AgroSolutions Ltd.
- Application: Novel herbicide intermediate
- Result: 40% cost reduction vs traditional routes
- Outcome: EPA approval in 3 countries
6. Request Customized Technical Support
Contact our chemistry experts for:
- Bulk pricing (100kg+ orders)
- Custom synthesis services
- Regulatory documentation support
Email: info@vivalr.com
Phone: (86) 15866781826
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