3-Amino-2-bromo-5-fluoropyridine: Comprehensive User Guide
Table of Contents
1. Product Overview and Specifications
| Parameter | Value |
|---|---|
| CAS Number | 884495-03-8 |
| Molecular Formula | C5H4BrFN2 |
| Molecular Weight | 191.00 g/mol |
| Appearance | Off-white to light yellow crystalline powder |
| Density | 1.8±0.1 g/cm3 |
| Melting Point | 114–116°C |
| Boiling Point | 273.6±35.0°C |
| Storage | 2–8°C, protected from light |
2. Applications and Use Cases
Primary Applications
3-Amino-2-bromo-5-fluoropyridine is a critical intermediate in pharmaceutical synthesis, particularly in:
- Anticancer Drug Development: Used to introduce fluorine and bromine substituents into pyridine-based scaffolds for targeted therapies.
- Antiviral Compounds: Facilitates the synthesis of nucleotide analogs for RNA virus inhibition.
- Agrochemicals: Serves as a building block for herbicides and fungicides with enhanced bioavailability.
Functional Advantages
- Enables precise regioselective modifications due to its reactive amino and halogen groups.
- Enhances metabolic stability in final API (Active Pharmaceutical Ingredient) formulations.
3. Industry Case Studies
Case Study 1: Oncology Research Institute
Challenge: Developing a tyrosine kinase inhibitor with improved selectivity.
Solution: Utilized 3-Amino-2-bromo-5-fluoropyridine to create a fluorinated pyridine core, achieving 85% higher target binding affinity.
Outcome: Advanced to preclinical trials with reduced off-target effects.
Case Study 2: Agrochemical Manufacturer
Challenge: Enhancing fungicide persistence under UV exposure.
Solution: Incorporated the compound into a triazole derivative, improving photostability by 40%.
Outcome: Product achieved EPA approval with extended field efficacy.
4. Contact for Inquiries
For technical specifications, bulk pricing, or custom synthesis requests:
| info@vivalr.com | |
| Phone | (86) 15866781826 |
| Lead Time | 2–5 business days (standard orders) |


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