3-Amino-2-bromo-5-fluoropyridine

Product Name:3-Amino-2-bromo-5-fluoropyridine
CAS:884495-03-8
MFC5H4BrFN2
MW:191
EINECS:629-495-7
MOL File:884495-03-8.mol

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3-Amino-2-bromo-5-fluoropyridine: Comprehensive User Guide

1. Product Overview and Specifications

Parameter Value
CAS Number 884495-03-8
Molecular Formula C5H4BrFN2
Molecular Weight 191.00 g/mol
Appearance Off-white to light yellow crystalline powder
Density 1.8±0.1 g/cm3
Melting Point 114–116°C
Boiling Point 273.6±35.0°C
Storage 2–8°C, protected from light

2. Applications and Use Cases

Primary Applications

3-Amino-2-bromo-5-fluoropyridine is a critical intermediate in pharmaceutical synthesis, particularly in:

  • Anticancer Drug Development: Used to introduce fluorine and bromine substituents into pyridine-based scaffolds for targeted therapies.
  • Antiviral Compounds: Facilitates the synthesis of nucleotide analogs for RNA virus inhibition.
  • Agrochemicals: Serves as a building block for herbicides and fungicides with enhanced bioavailability.

Functional Advantages

  • Enables precise regioselective modifications due to its reactive amino and halogen groups.
  • Enhances metabolic stability in final API (Active Pharmaceutical Ingredient) formulations.

3. Industry Case Studies

Case Study 1: Oncology Research Institute

Challenge: Developing a tyrosine kinase inhibitor with improved selectivity.
Solution: Utilized 3-Amino-2-bromo-5-fluoropyridine to create a fluorinated pyridine core, achieving 85% higher target binding affinity.
Outcome: Advanced to preclinical trials with reduced off-target effects.

Case Study 2: Agrochemical Manufacturer

Challenge: Enhancing fungicide persistence under UV exposure.
Solution: Incorporated the compound into a triazole derivative, improving photostability by 40%.
Outcome: Product achieved EPA approval with extended field efficacy.

4. Contact for Inquiries

For technical specifications, bulk pricing, or custom synthesis requests:

Email info@vivalr.com
Phone (86) 15866781826
Lead Time 2–5 business days (standard orders)

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