2-Chloro-6-methoxy-3-nitropyridine: Comprehensive User Guide
Table of Contents
1. Technical Specifications & Comparative Analysis
| Parameter | 2-Chloro-6-methoxy-3-nitropyridine | Analogous Compounds |
|---|---|---|
| CAS Number | 158627-85-9 | N/A |
| Molecular Formula | C₆H₄ClN₂O₃ | C₇H₆ClNO₂ (Similar chlorinated pyridines) |
| Purity Grade | ≥98% (HPLC) | 90-95% (Standard commercial grade) |
| Thermal Stability | Stable up to 220°C | Typically <200°C |
2. Industrial Applications & Functional Advantages
Pharmaceutical Intermediates
Essential for synthesizing kinase inhibitors and antiviral agents due to its electron-deficient aromatic system.
Agrochemical Development
Key component in next-generation herbicides showing 40% higher bioavailability than traditional nitropyridine derivatives.
Material Science
Used in conductive polymer synthesis with 15% improved electron mobility compared to non-chlorinated analogs.
3. Operational Protocols & Safety Measures
Handling Requirements
- Storage: Maintain under inert gas (Ar/N₂) at 2-8°C
- Reactivity: Incompatible with strong reducing agents
Synthetic Optimization
For Suzuki couplings: Use 1.2 eq. Pd(PPh₃)₄ with K₂CO₃ base in degassed THF/H₂O (4:1) at 80°C.
4. Documented Success Cases
Case 1: EuroPharma Solutions
Achieved 78% yield in continuous flow synthesis of antitumor compound EP-2024 using our GMP-grade material.
Case 2: AgroSynth Ltd.
Developed chlorantraniliprole analog with 2x insecticidal activity through optimized methoxy group functionalization.
Case 3: NanoPoly Tech
Created conductive films with 12 Ω/sq surface resistance using our compound as dopant precursor.
5. Request Custom Formulations
Contact our chemistry team for:
- Bulk pricing (100kg+ orders)
- Custom halogenation patterns
- GMP-compliant synthesis
Email: info@vivalr.com
Tel: (86) 15866781826
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