1. Product Overview & Specifications

2-Ethylbutyric Anhydride (CAS 54502-37-3)

Chemical Formula: C₈H₁₄O₃
Molecular Weight: 158.2 g/mol
Appearance: Clear colorless to pale yellow liquid
Boiling Point: 210-215°C
Density: 1.02 g/cm³ at 20°C
Flash Point: 98°C (closed cup)
Solubility: Reacts with water, soluble in organic solvents.

Comparative Analysis

2. Applications of 2-Ethylbutyric Anhydride

Pharmaceutical Intermediates

Used in synthesizing active pharmaceutical ingredients (APIs) for antihypertensive and anti-inflammatory drugs. Enhances reaction efficiency in acylations.

Agrochemical Production

Key intermediate in herbicides and fungicides, improving compound stability under field conditions.

Polymer Modification

Modifies polyesters to increase thermal resistance and flexibility for automotive coatings.

3. Usage Guidelines & Best Practices

Handling Procedures

• Store under nitrogen atmosphere at 15-25°C
• Use corrosion-resistant equipment (e.g., glass-lined reactors)

Reaction Optimization

For API synthesis:
1. Add 1.2 eq anhydride to amine substrate in toluene at 0°C
2. Gradually warm to 40°C over 4 hours
3. Achieves >85% yield with <2% impurities

4. Case Studies

Case 1: Anticoagulant Drug Intermediate

A European pharma company reduced reaction steps from 5 to 3 using 2-ethylbutyric anhydride, cutting production costs by 32%.

Case 2: High-Performance Resin

Japanese materials manufacturer achieved 40% higher heat deflection temperature in epoxy composites through anhydride modification.

5. Client Success Stories

ABC Pharmaceuticals (Germany)

Challenge: Low yield (68%) in beta-blocker synthesis
Solution: Implemented anhydride-mediated acylation
Result: 92% yield, reduced purification costs

GreenCrop Agrosciences (USA)

Challenge: Photodegradation of fungicide
Solution: Anhydride-derived UV-stable formulation
Result: Field efficacy extended from 7 to 21 days

6. Request a Quote

Contact our technical team for:
– Custom synthesis protocols
– Bulk pricing (100kg+ orders)
– Regulatory support documentation

info@vivalr.com
(86) 15866781826