2-Chloropyridine-3-sulfonyl chloride

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2-Chloropyridine-3-sulfonyl chloride: Comprehensive Product Guide

Table of Contents

1. Product Overview & Specifications

Parameter Specification
CAS Number 6602-54-6
Molecular Formula C5H3Cl2NO2S
Appearance White to pale yellow crystalline powder
Purity ≥98.5% (HPLC)
Melting Point 89-92°C
Storage Conditions 2-8°C in inert atmosphere

Comparative Analysis with Similar Reagents

Feature 2-Chloropyridine-3-sulfonyl chloride Pyridine-2-sulfonyl chloride
Reactivity High electrophilicity Moderate
Stability Air-sensitive Stable
Pharma Applications API intermediates Limited

2. Key Applications & Industrial Uses

Widely utilized as sulfonating agent in:

  • Pharmaceutical intermediates for antiretroviral drugs
  • Agrochemical synthesis (herbicide precursors)
  • Polymer modification catalysts
  • Ligand synthesis for transition metal complexes

3. Performance Comparison Analysis

Superior characteristics include:

  • 30% higher reaction yield vs. analogues
  • Reduced byproduct formation (≤2.7%)
  • Compatible with Grignard reactions

4. Operational Guidelines

Recommended protocols:

  1. Maintain N2 atmosphere during handling
  2. Use anhydrous solvents (THF/DCM)
  3. Reaction temp: 0-5°C for optimal control

5. Industry Application Cases

Case 1: Antiviral Drug Synthesis

Client: Top 10 Global Pharma Company
Application: Key intermediate for HCV protease inhibitor
Result: 22% yield improvement vs previous process

Case 2: Herbicide Development

Client: EU Agrochem Leader
Application: Sulfonylurea herbicide precursor
Result: Achieved 99.1% purity in final product

Case 3: Polymer Modification

Client: Specialty Materials Manufacturer
Application: Surface functionalization agent
Result: Enhanced thermal stability by 40°C

6. Technical Consultation & Quotation

Contact our chemical engineers for:

  • Custom synthesis solutions
  • Bulk order pricing (50kg+ quantities)
  • Technical documentation (MSDS, COA)

Email: info@vivalr.com
Tel: (86) 15866781826

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