Contents
1-Naphthylboronic Acid (CAS 13922-41-3): Technical Specifications and Comparative Analysis
Core Parameters
| Parameter | Specification |
|---|---|
| CAS Number | 13922-41-3 |
| Molecular Formula | C10H9BO2 |
| Molecular Weight | 171.99 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥98.5% |
| Melting Point | 215-220°C |
| Storage Conditions | 2-8°C in inert atmosphere |
Comparative Analysis
| Property | 1-Naphthylboronic Acid | Phenylboronic Acid | 2-Naphthylboronic Acid |
|---|---|---|---|
| Reactivity Index | 0.87 | 0.92 | 0.79 |
| Aqueous Solubility | 3.2 mg/mL | 8.1 mg/mL | 2.7 mg/mL |
| Thermal Stability | Superior | Moderate | High |
2. Industrial Applications of 1-Naphthylboronic Acid
Pharmaceutical Intermediates
Critical precursor in Suzuki-Miyaura cross-couplings for:
- Kinase inhibitor synthesis
- Anticancer drug development
- Protease-activated receptor antagonists
Material Science Applications
- OLED material synthesis
- Conductive polymer modification
- Coordination polymer frameworks
3. Technical Implementation Case Studies
Case 1: Antiviral Drug Synthesis
Reaction: Palladium-catalyzed coupling with 4-bromobenzotrifluoride
Yield: 82% under optimized conditions
Scale: 15kg batch production
Case 2: Organic Semiconductor Development
Application: Electron-transport layer modification
Result: 18% efficiency improvement in OLED devices
Process: Solution-phase deposition at 120°C
4. Verified Client Implementations
Client A: Top-tier Pharmaceutical Company
| Parameter | Detail |
|---|---|
| Application | PARP inhibitor intermediate synthesis |
| Annual Consumption | 320kg |
| Process Benefit | Reduced catalyst loading by 40% |
Client B: Advanced Materials Manufacturer
| Parameter | Detail |
|---|---|
| Application | Conductive polymer side-chain modification |
| Result | Achieved σ = 1.2 × 103 S/cm |
| Batch Consistency | 99.2% purity across 12 production lots |
5. Procurement Guidance for Industrial Buyers
Technical Specifications Checklist
- Confirm HPLC purity ≥98.5%
- Require residual solvent analysis (DMSO <0.1%)
- Verify boron content: 6.15-6.35%
Supplier Evaluation Criteria
| Factor | Weight | Evaluation Metric |
|---|---|---|
| Batch Consistency | 30% | ±0.3% purity variance |
| Documentation | 25% | Complete COA/MSDS |
| Scalability | 20% | 100kg+ production capacity |
6. Commercial Inquiry & Technical Support
Contact Our Expert Team
For technical specifications, bulk pricing, or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
Request Custom Documentation
- Detailed COA templates
- Safety handling protocols
- Scale-up feasibility reports
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