1. Product Overview & Specifications

3-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine (CAS No. 1073353-95-6) is a high-purity boronic ester intermediate widely used in Suzuki-Miyaura cross-coupling reactions. Key parameters:

2. Key Applications

• Pharmaceutical Synthesis: Critical intermediate for kinase inhibitors and oncology drugs
• Material Science: Building block for OLED/OPV materials
• Agrochemicals: Precursor for novel pesticide development

3. Usage Guidelines

Typical Suzuki Reaction Protocol:

1. Use 1.2 eq of boronic ester in anhydrous THF
2. Maintain reaction temperature at 60-80°C
3. Employ Pd(PPh3)4 (2 mol%) as catalyst

4. Case Studies

Case 1: Synthesis of Bruton’s tyrosine kinase (BTK) inhibitor analogues achieved 82% yield using this boronic ester under microwave conditions.

Case 2: Enabled production of blue-emitting OLED materials with 15% improved luminance efficiency.

5. Client Success Stories

ABC Pharma (Germany): Reduced lead compound synthesis time from 14 to 6 days through optimized coupling reactions.

XYZ Agrochemicals (USA): Developed next-gen fungicide with 30% higher field efficacy using this intermediate.

Material Innovators Co. (Japan): Patented flexible OLED film technology leveraging the compound’s stability.

6. Contact for Quotations

Request custom synthesis quantities (1g to 10kg scale):

info@vivalr.com
(86) 15866781826

All compounds ship with NMR/HPLC/LCMS documentation.