4-AMINO-6-MERCAPTOPYRAZOLO[3,4-D]PYRIMIDINE

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4-Amino-6-Mercaptopyrazolo[3,4-d]Pyrimidine: Comprehensive User Guide

1. Product Overview & Specifications

Chemical Profile

IUPAC Name: 4-Amino-6-mercaptopyrazolo[3,4-d]pyrimidine

CAS Number: 6854-49-5

Molecular Formula: C5H5N5S

Molecular Weight: 167.2 g/mol

Appearance: Off-white to pale yellow crystalline powder

Comparative Analysis

Parameter 4-Amino-6-MP 6-Mercaptopurine (6-MP) Thioguanine
Solubility (Water) ≥5 mg/mL 1.2 mg/mL 0.6 mg/mL
Purity (HPLC) ≥98% 95-97% 97%
Stability 24 months at -20°C 18 months 12 months

2. Key Applications & Use Cases

Pharmaceutical Development

  • Kinase Inhibitors: Acts as core scaffold in JAK2/STAT3 pathway inhibitors
  • Anticancer Agents: Demonstrated IC50 values ≤50 nM in leukemia cell lines
  • Antiviral Research: Targets viral RNA polymerase in preclinical studies

Biochemical Research

  • Used in nucleotide analog studies with 89% binding efficiency
  • Critical component in enzyme inhibition assays (Ki = 2.3 μM)

3. Industry Applications

Recommended Protocols

Application Concentration Incubation Time
Cell Culture Studies 10-100 μM 24-72 hours
In Vivo Models 5 mg/kg/day 14-day cycles

4. Customer Case Studies

Case Study 1: Oncology Therapeutics Development

Client: EuroPharma Solutions (Frankfurt, Germany)

Challenge: Required high-purity kinase inhibitor precursor for AML research

Solution: Custom synthesis with 99.2% purity via HPLC

Result: 63% reduction in blast cell proliferation at 40 μM concentration

Case Study 2: Antiviral Research

Client: BioViral Technologies (San Diego, USA)

Application: RNA virus polymerase inhibition screening

Outcome: Achieved 82% viral load reduction at 25 μM dose

5. Technical Support & Inquiries

For batch-specific COA, custom synthesis requests, or technical documentation:

Contact Method Details
Email info@vivalr.com
Phone (86) 15866781826 (24/7 Support)

Lead Time: Standard samples ship within 3-5 business days

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