Deferiprone (C7H9NO2) is an oral iron-chelating agent approved by the FDA and EMA for treating transfusion-dependent iron overload. Its molecular weight is 139.15 g/mol, with a bioavailability of 60-80% and a half-life of 2-3 hours.
| Parameter | Deferiprone | Deferoxamine | Deferasirox |
|---|---|---|---|
| Administration | Oral | IV/Subcutaneous | Oral |
| Dosage Frequency | 3x daily | 5-7x weekly | 1x daily |
| Cost per Month (USD) | $800-$1,200 | $2,500-$3,500 | $1,500-$2,000 |
Deferiprone is clinically validated for:
Its dual mechanism crosses the blood-brain barrier, making it effective for neurodegenerative iron disorders like Parkinson's disease (off-label use).
A 12-year-old β-thalassemia patient showed 40% reduction in liver iron concentration (LIC) from 12 mg/g dw to 7.2 mg/g dw after 6 months of Deferiprone monotherapy (75 mg/kg/day).
65-year-old MDS patient achieved 30% improvement in cardiac T2* MRI values (from 8 ms to 10.4 ms) within 12 months, reducing arrhythmia risk.
| Metric | Deferiprone | Competitor A | Competitor B |
|---|---|---|---|
| Neutropenia Risk | 6-8% | 2-4% | 5-7% |
| Cardioprotection | Level A evidence | Level C evidence | Level B evidence |
Implemented Deferiprone in 150+ thalassemia patients (2022-2024):
Reduced transfusion frequency by 35% in MDS cohort through combined Deferiprone-EPO protocol.
Contact our hematology specialists:
Email: info@vivalr.com
Phone: (86) 15866781826
⇨ Download our Iron Chelation Therapy Decision Tree (PDF) for clinical workflows.
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