Abstract
This article provides an in-depth guide to (-)-Di-P-Toluoyl-L-Tartaric Acid, a chemical compound with the CAS number 32634-66-5. It covers its properties, applications, synthesis methods, safety considerations, and regulatory information, offering a comprehensive understanding of this compound for both professionals and enthusiasts in the field of chemistry.
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Introduction to (-)-Di-P-Toluoyl-L-Tartaric Acid
(-)-Di-P-Toluoyl-L-Tartaric Acid, also known as di-tartaric acid, is a synthetic compound derived from tartaric acid. It is a white crystalline powder that is widely used in various industries due to its unique properties. This guide will delve into the details of (-)-Di-P-Toluoyl-L-Tartaric Acid, including its chemical structure, physical properties, and applications.
Chemical Structure and Properties
(-)-Di-P-Toluoyl-L-Tartaric Acid has a molecular formula of C18H16O10 and a molecular weight of 392.34 g/mol. It is a racemic mixture of enantiomers, with the (-)-enantiomer being the most commonly used form. The compound is characterized by its crystalline nature and its solubility in water and organic solvents. Its chemical structure allows it to act as a chiral resolving agent, which is crucial in the pharmaceutical industry for separating enantiomers.
Physical Properties
(-)-Di-P-Toluoyl-L-Tartaric Acid is a white crystalline powder that is odorless and tasteless. It has a melting point of approximately 200°C and is stable under normal conditions. The compound is slightly soluble in water and more soluble in organic solvents such as ethanol and acetone. These physical properties make it suitable for various applications, including pharmaceuticals, food, and cosmetics.
Applications in the Pharmaceutical Industry
(-)-Di-P-Toluoyl-L-Tartaric Acid is widely used in the pharmaceutical industry for its ability to resolve chiral compounds. It is often used in the synthesis of chiral drugs, where the enantiomers have different biological activities. Additionally, it serves as a stabilizer and excipient in tablet formulations, improving the shelf life and bioavailability of drugs.
Use in Food and Cosmetics
(-)-Di-P-Toluoyl-L-Tartaric Acid is also utilized in the food and cosmetics industries. In food, it acts as an acidulant, stabilizer, and preservative, enhancing the flavor and shelf life of products. In cosmetics, it is used as a pH adjuster and emulsifier, contributing to the texture and stability of formulations.
Synthesis Methods
The synthesis of (-)-Di-P-Toluoyl-L-Tartaric Acid involves the esterification of tartaric acid with p-toluenesulfonyl chloride. This process is typically carried out in an organic solvent, such as dichloromethane, and requires a catalyst to facilitate the reaction. The resulting diester is then purified through recrystallization to obtain the desired compound.
Safety Considerations
(-)-Di-P-Toluoyl-L-Tartaric Acid is considered safe for use in the concentrations typically found in industrial applications. However, it is important to handle the compound with care, as it can cause irritation to the skin, eyes, and respiratory system. Adequate ventilation and personal protective equipment should be used when working with this compound.
Regulatory Information
(-)-Di-P-Toluoyl-L-Tartaric Acid is subject to regulatory oversight in various countries. The European Food Safety Authority (EFSA) and the U.S. Food and Drug Administration (FDA) have evaluated its safety and have established maximum allowable concentrations for use in food and pharmaceutical products. Compliance with these regulations is essential for manufacturers and users of the compound.
Conclusion
(-)-Di-P-Toluoyl-L-Tartaric Acid, with its unique properties and applications, is a significant compound in various industries. This guide has provided an overview of its chemical structure, physical properties, synthesis methods, safety considerations, and regulatory information. Understanding these aspects is crucial for professionals and enthusiasts in the field of chemistry, ensuring safe and effective use of this compound.
Keywords: (-)-Di-P-Toluoyl-L-Tartaric Acid, CAS 32634-66-5, chemical properties, applications, synthesis, safety, regulatory information.
