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Specialized inAbemaciclib Cas 1231929-97-7and related product development and production

Chemical Name: Abemaciclib
CAS No.: 1231929-97-7
Molecular Formula: C27H32F2N8
Molecular Weight: 506.59

Samples: Available / Stock: Sufficient
Estimated delivery time: 3-5 days

Table of Contents

Abemaciclib (CAS 1231929-97-7) Overview

Chemical Profile

Parameter Description
CAS Number 1231929-97-7
Molecular Formula C27H32N8O
Molecular Weight 480.6 g/mol
Appearance White to yellow crystalline powder
Storage 2-8°C protected from light

Comparative Analysis of CDK4/6 Inhibitors

Parameter Abemaciclib Palbociclib Ribociclib
Bioavailability 45% 46% 60-70%
Half-life 18.3h 29h 32.0h
Dosing Frequency Twice daily Once daily Once daily
FDA Approval 2017 2015 2017

Therapeutic Applications

Primary Indications

  • HR+/HER2- advanced or metastatic breast cancer (combined with endocrine therapy)
  • Adjuvant treatment of early breast cancer with high recurrence risk

Mechanism of Action

Selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), disrupting cell cycle progression from G1 to S phase.

Clinical Usage Guidelines

Dosing Protocol

Patient Type Dosage Duration
Adults (monotherapy) 200mg twice daily Continuous until disease progression
Combination therapy 150mg twice daily + fulvestrant 28-day cycles

Adverse Effect Management

  • Diarrhea: Implement loperamide prophylaxis
  • Neutropenia: Monitor CBC every 2 weeks
  • Hepatotoxicity: Monthly liver function tests

Clinical Case Studies

Case Study 1: Metastatic Breast Cancer (MONARCH 2 Trial)

Patient: 52-year-old female with HR+/HER2- metastatic breast cancer
Regimen: Abemaciclib 150mg BID + fulvestrant 500mg
Outcome: Median progression-free survival 16.4 months vs 9.3 months in placebo arm

Case Study 2: Early Breast Cancer (monarchE Trial)

Patient Cohort: 5,637 patients with high-risk early breast cancer
Regimen: Adjuvant abemaciclib + endocrine therapy
Outcome: 32% reduction in invasive disease recurrence

Contact for Pharmaceutical Procurement

For bulk orders or clinical trial supplies:
Email: info@vivalr.com
Tel: (86) 15866781826

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This is William, CEO of fousi chemical Chemical Co., Ltd.

Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.

Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

Does it support auditing?

Support, please make an appointment one day in advance. Company address: Room 716, Building 3, Ligao International Garden, No.1222 West Aoti Road, Lixia District, Jinan City, Shandong Province, P.R. China

Whether to provide samples?

Free samples can be provided for low value products, and small packaging specifications can be purchased for high value products.

Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

User’evaluation of us

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Michael Cooper

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James Black

" Sincere Chemical team visited our USA factory in the year of 2017. We think highly of cooperation with them. We thanked you for the past excellent orders and best product quality. We also talked about some new products for future orders. We will be still in strategic cooperation in the future and help each other."

Lisa Goodwill

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