2,2′-AZOBIS[2-(2-IMIDAZOLIN-2-YL)PROPANE] DIHYDROCHLORIDE CAS 27776-21-2: Ultimate Guide
Table of Contents
- Product Overview & Specifications
- Comparative Analysis with Similar Initiators
- Key Industrial Applications
- Operational Protocols & Safety Measures
- Industry Implementation Case Studies
- Technical Consultation & Purchasing
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 2,2′-Azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride |
| CAS Number | 27776-21-2 |
| Molecular Formula | C₁₄H₂₄Cl₂N₈ |
| Molecular Weight | 383.3 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity | ≥98% (HPLC) |
| Decomposition Temp | 50-60°C (10h half-life in water) |
| Solubility | Water >50 mg/mL |
2. Comparative Analysis with Similar Initiators
| Feature | V-50 | AIBN | ACVA |
|---|---|---|---|
| Water Solubility | Excellent | Poor | Moderate |
| Optimal Temp Range | 40-70°C | 60-80°C | 50-75°C |
| pH Tolerance | 3-10 | Neutral | 4-9 |
| Polymerization Rate | 0.12 min⁻¹ | 0.08 min⁻¹ | 0.10 min⁻¹ |
| FDA Compliance | Pharmaceutical Grade Available | Industrial Only | Limited |
3. Key Industrial Applications
3.1 Free Radical Polymerization
Preferred for aqueous systems in synthesizing:
- Acrylamide-based flocculants (MW >10⁶ Da)
- Temperature-responsive hydrogels (LCST 32-40°C)
- Drug-loaded micelles (10-200 nm particle size)
3.2 Biomedical Engineering
Critical in manufacturing:
- Smart wound dressings with pH-responsive drug release
- 3D printable bio-inks (25-40°C gelation)
- Antimicrobial surface coatings (5-log reduction)
4. Operational Protocols & Safety Measures
4.1 Standard Polymerization Procedure
- Prepare 0.1-0.3 wt% initiator solution in deoxygenated DI water
- Maintain nitrogen blanket (O₂ < 0.5 ppm)
- Initiate reaction at 50±2°C for 6-8 hours
- Post-polymerization dialysis (MWCO 10kDa)
4.2 Safety Protocols
- PPE Requirements: Neoprene gloves, full-face shield
- Storage: Argon-purged container at 4°C
- Deactivation: 0.5M NaOH solution (1:10 ratio)
5. Industry Implementation Case Studies
5.1 PharmaTech Solutions (Germany)
Application: Sustained-release insulin formulation
Results: 72-hour release profile with 92% bioactivity retention
Process: 0.2% V-50 in phosphate buffer (pH 7.4), 45°C polymerization
5.2 AquaPurge LLC (USA)
Application: Heavy metal-chelating hydrogels
Performance: 98% Pb²⁺ removal at 50 ppm concentration
Formulation: 2:1 acrylamide:V-50 ratio, 55°C curing
6. Technical Consultation & Purchasing
Contact our polymer science team for:
- Custom initiator formulations
- Bulk pricing (100kg+ orders)
- GMP-certified production options
Reach us at:
Email: info@vivalr.com
Phone: (86) 15866781826



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