2,2′-AZOBIS[2-(2-IMIDAZOLIN-2-YL)PROPANE] DIHYDROCHLORIDE CAS 27776-21-2

Chemical Name: 2,2′-AZOBIS[2-(2-IMIDAZOLIN-2-YL)PROPANE] DIHYDROCHLORIDE
CAS No.: 27776-21-2
Molecular Fomula: C12H23ClN6
Molecular weight:286.81
Appearance: White to off-white powder

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2,2′-AZOBIS[2-(2-IMIDAZOLIN-2-YL)PROPANE] DIHYDROCHLORIDE CAS 27776-21-2: Ultimate Guide

Table of Contents

1. Product Overview & Specifications

Parameter Specification
Chemical Name 2,2′-Azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride
CAS Number 27776-21-2
Molecular Formula C₁₄H₂₄Cl₂N₈
Molecular Weight 383.3 g/mol
Appearance White to pale yellow crystalline powder
Purity ≥98% (HPLC)
Decomposition Temp 50-60°C (10h half-life in water)
Solubility Water >50 mg/mL

2. Comparative Analysis with Similar Initiators

Feature V-50 AIBN ACVA
Water Solubility Excellent Poor Moderate
Optimal Temp Range 40-70°C 60-80°C 50-75°C
pH Tolerance 3-10 Neutral 4-9
Polymerization Rate 0.12 min⁻¹ 0.08 min⁻¹ 0.10 min⁻¹
FDA Compliance Pharmaceutical Grade Available Industrial Only Limited

3. Key Industrial Applications

3.1 Free Radical Polymerization

Preferred for aqueous systems in synthesizing:

  • Acrylamide-based flocculants (MW >10⁶ Da)
  • Temperature-responsive hydrogels (LCST 32-40°C)
  • Drug-loaded micelles (10-200 nm particle size)

3.2 Biomedical Engineering

Critical in manufacturing:

  • Smart wound dressings with pH-responsive drug release
  • 3D printable bio-inks (25-40°C gelation)
  • Antimicrobial surface coatings (5-log reduction)

4. Operational Protocols & Safety Measures

4.1 Standard Polymerization Procedure

  1. Prepare 0.1-0.3 wt% initiator solution in deoxygenated DI water
  2. Maintain nitrogen blanket (O₂ < 0.5 ppm)
  3. Initiate reaction at 50±2°C for 6-8 hours
  4. Post-polymerization dialysis (MWCO 10kDa)

4.2 Safety Protocols

  • PPE Requirements: Neoprene gloves, full-face shield
  • Storage: Argon-purged container at 4°C
  • Deactivation: 0.5M NaOH solution (1:10 ratio)

5. Industry Implementation Case Studies

5.1 PharmaTech Solutions (Germany)

Application: Sustained-release insulin formulation
Results: 72-hour release profile with 92% bioactivity retention
Process: 0.2% V-50 in phosphate buffer (pH 7.4), 45°C polymerization

5.2 AquaPurge LLC (USA)

Application: Heavy metal-chelating hydrogels
Performance: 98% Pb²⁺ removal at 50 ppm concentration
Formulation: 2:1 acrylamide:V-50 ratio, 55°C curing

6. Technical Consultation & Purchasing

Contact our polymer science team for:

  • Custom initiator formulations
  • Bulk pricing (100kg+ orders)
  • GMP-certified production options

Reach us at:
Email: info@vivalr.com
Phone: (86) 15866781826

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