Table of Contents
Lodoethane (CAS 75-03-6) Technical Profile
Basic Properties
| Parameter | Specification |
|---|---|
| CAS Number | 75-03-6 |
| IUPAC Name | Iodoethane |
| Molecular Formula | C2H5I |
| Molecular Weight | 155.97 g/mol |
| Appearance | Clear colorless to pale yellow liquid |
| Boiling Point | 72°C at 760 mmHg |
| Density | 1.93 g/cm3 at 25°C |
| Refractive Index | n20D 1.513-1.515 |
| Purity | ≥98% (GC analysis) |
Halogenated Ethane Comparison
| Property | Iodoethane | Bromoethane | Chloroethane |
|---|---|---|---|
| Reactivity | High (SN2 reactions) | Moderate | Low |
| Stability | Light-sensitive | Air-stable | Highly stable |
| Cost Efficiency | Premium pricing | Mid-range | Economical |
| Application Scope | Specialty synthesis | General alkylation | Industrial uses |
Industrial & Research Applications
Pharmaceutical Manufacturing
Essential intermediate for:
- Antiviral drug synthesis (e.g., reverse transcriptase inhibitors)
- Radioactive contrast agent preparation
- Quaternary ammonium compound production
Agrochemical Development
- Key component in soil fumigants
- Precursor for herbicidal compounds
- Pheromone synthesis for pest control
Operational Best Practices
Storage Requirements
- Amber glass containers under inert gas
- Temperature: 2-8°C (long-term storage)
- Separate from strong oxidizers
Reaction Protocols
- Optimal reaction temperature: 40-60°C
- Recommended solvent: Anhydrous THF or DMF
- Typical catalyst: Potassium carbonate
Implementation Case Studies
Pharmaceutical API Synthesis
Challenge: Improve yield in nucleoside analog production
Solution: Implemented iodoethane in Mitsunobu reaction
Result: 92% yield improvement vs bromoethane alternative
Polymer Modification
Project: Surface functionalization of medical-grade silicone
Process: Gas-phase alkylation using Lodoethane vapor
Outcome: 40% increase in hydrophobicity
Client Success Stories
ABC Pharmaceuticals (Germany)
- Application: Antiretroviral medication R&D
- Annual Consumption: 850kg
- Key Benefit: Reduced synthesis steps from 7 to 4
AgroChem Solutions Ltd (USA)
- Use Case: Novel fungicide development
- Project Duration: 18-month collaboration
- Achievement: Accelerated EPA approval timeline by 30%
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