2,4-Difluorobenzoic Acid (CAS 1583-58-0): Comprehensive Technical Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 1583-58-0 |
| Molecular Formula | C7H4F2O2 |
| Molecular Weight | 158.1 g/mol |
| Appearance | White crystalline solid |
| Melting Point | 186-190°C |
| Boiling Point | 239.5°C at 760 mmHg |
| Density | 1.432 g/cm³ |
| Solubility | Soluble in ethanol, methanol, DCM; limited water solubility |
| Flash Point | 98.6°C |
2. Key Applications
Core Industrial Uses:
- Pharmaceutical Intermediate: Critical component in antifungal agents (Fluconazole, Voriconazole)
- Polymer Engineering: Catalyst/stabilizer for high-performance polymers (polyimides, polyesters)
- Advanced Materials: Precursor for liquid crystal displays (LCDs) and optical films
- Agrochemical Synthesis: Building block for fluorinated pesticides
3. Synthesis Methods
Production Pathways:
| Method | Key Steps | Yield Improvement |
|---|---|---|
| Traditional Process | 1. m-Dinitrobenzene reduction 2. Diazotization 3. Fluorination 4. Acylation 5. Oxidation |
65-70% |
| Optimized Process | 1. o-Nitrotoluene nitration 2. Catalytic oxidation 3. Phase-transfer fluorination (PEG-1500) |
82-85% |
4. Safety Protocols
| Hazard | Precaution | Emergency Response |
|---|---|---|
| Skin Irritation (H315) | Wear nitrile gloves & chemical apron | Flush with water ≥15 minutes |
| Eye Damage (H319) | Use ANSI-approved goggles | Irrigate eyes with saline solution |
| Respiratory Risk (H335) | NIOSH-approved respirator required | Administer oxygen if inhaled |
Storage: Maintain in sealed containers at 15-25°C with ≤60% RH. Separate from oxidizers.
5. Industry Use Cases
Case Study 1: Antifungal API Production
Client: Leading European Pharma Manufacturer
Application: Fluconazole intermediate synthesis
Results: Achieved 99.2% purity meeting EP 10.0 standards
Case Study 2: Specialty Polymers
Client: US Advanced Materials Company
Application: High-temperature polyimide production
Results: Enhanced thermal stability (Tg increased by 28°C)
Case Study 3: Display Technologies
Client: Asian LCD Manufacturer
Application: Liquid crystal alignment layers
Results: Improved response time (4ms → 2.3ms)
6. Procurement Guidance
Available Specifications:
– Technical Grade: ≥97% purity
– Pharmaceutical Grade: ≥99.5% purity (USP/EP compliant)
Certified Suppliers:
– Wuhan NewGreat Chemical Co., Ltd. (ISO 9001:2015 certified)
– Guangzhou Bester Chemical Co., Ltd. (GMP-compliant facility)
Contact for Technical Consultation:
Email: info@vivalr.com
Tel: (86) 15866781826
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