4-Hydroxyphenylacetic Acid CAS 156-38-7

Chemical Name: 4-Hydroxyphenylacetic acid
CAS No.: 156-38-7
Molecular Formula: C8H8O3
Molecular Weight: 152.15

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4-Hydroxyphenylacetic Acid (CAS 156-38-7) Comprehensive Guide

Table of Contents

Product Information & Specifications

CAS Number 156-38-7
Molecular Formula C8H8O3
Molecular Weight 152.15 g/mol
Appearance White crystalline powder
Melting Point 148-151°C
Boiling Point 346.6°C at 760 mmHg
Solubility 50 g/L in water (20°C)
Flash Point 177.6°C

Parameter Comparison

Supplier Purity Packaging Price Range
Shandong Xuchen Chemical Premium Grade 25kg/drum $16.8/kg
Jiangsu Pulse Biological 99% Customized Negotiable
Beijing North Standards Analytical Standard 100mg/vial $280/vial

Industrial Applications

Pharmaceutical Intermediate

Essential in synthesizing β-(4-hydroxyphenyl)ethanol (51.2% yield via ester reduction) and active pharmaceutical ingredients including Atenolol impurities and Levothyroxine Sodium impurities.

Antioxidant Agent

Functions as a microbiota-derived polyphenol metabolite with demonstrated radical scavenging properties in biochemical research.

Chemical Synthesis

Precursor for methyl 4-hydroxyphenylacetate (CAS 14199-15-6), used in specialty ester production with melting point 55-58°C.

Usage Scenarios

Quality Control Standards

Validated reference material for HPLC analysis of cardiovascular drugs, meeting pharmacopeia impurity profiling requirements.

Organic Synthesis

Key building block in peptide coupling reactions and chiral compound synthesis for advanced material science applications.

Biochemical Research

Used in gut microbiome studies to quantify phenolic acid metabolites through LC-MS detection methods.

Client Case Studies

Case 1: Pharmaceutical Manufacturer (Shandong, China)

Procured 500kg batch for Atenolol API production, achieving impurity profile compliance with ICH Q3B guidelines. Continuous quarterly orders maintained since Q3 2024.

Case 2: Research Institute (California, USA)

Utilized 4-Hydroxyphenylacetic Acid in longitudinal microbiome study, publishing findings in Nature Metabolism (2024) with 98.7% analytical purity verification.

Case 3: Chemical Distributor (Germany)

Integrated into European supply chain network, supplying 2-5MT monthly to specialty chemical producers with Just-in-Time delivery compliance.

Contact for Technical Consultation

Email: info@vivalr.com
Phone: (86) 15866781826

Request batch-specific COA, MSDS documentation, or discuss bulk procurement terms. Our chemical engineering team provides application support within 24 hours.

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