Clopidogrel Bisulfate CAS 120202-66-6
Chemical Name: Clopidogrel Bisulfate
Synonyms: Clopidogrel Hydrogen Shlfate; Clopidogrel HeMisulfate; Clopidogrel hydrogensulfate salt; (S)-(+)-Clopidogrel
CAS No.: 120202-66-6
Molecular Formula: C16H16ClNO2S.H2O4S
Molecular Weight: 419.9
Appearance: white powder
Clopidogrel Bisulfate (CAS 120202-66-6): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Clopidogrel Bisulfate (CAS 120202-66-6) is a potent antiplatelet agent widely used in cardiovascular therapeutics. Below are its key specifications:
| Parameter | Specification |
|---|---|
| Chemical Name | Methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate sulfate |
| Molecular Formula | C16H16ClNO2S·H2SO4 |
| Molecular Weight | 419.9 g/mol |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in methanol, slightly soluble in water |
| Purity | ≥99% (HPLC) |
| Storage | 2-8°C in airtight container |
Comparative Analysis
| Feature | Clopidogrel Bisulfate | Aspirin | Ticagrelor |
|---|---|---|---|
| Mechanism | P2Y12 ADP receptor inhibitor | COX-1 inhibitor | Reversible P2Y12 antagonist |
| Bioavailability | >50% | 80-100% | 36% |
| Half-life | 6-8 hours | 2-3 hours | 7-9 hours |
2. Key Applications & Uses
Medical Applications
- Acute coronary syndrome (ACS) management
- Post-stent implantation therapy
- Secondary prevention of myocardial infarction
- Peripheral artery disease treatment
Research Applications
- Pharmacokinetic studies
- Drug-drug interaction research
- Platelet aggregation inhibition analysis
3. Usage Guidelines
Recommended Dosage
| Condition | Loading Dose | Maintenance Dose |
|---|---|---|
| ACS | 300-600 mg | 75 mg/day |
| Stroke Prevention | 75 mg | 75 mg/day |
Administration Protocols
- Take with/without food
- Avoid concomitant use with PPIs
- Monitor for bleeding signs
4. Case Studies
Case 1: Hospital Cardiovascular Unit
Challenge: High post-PCI thrombosis rates
Solution: Implemented 300 mg loading dose protocol
Result: 62% reduction in thrombotic events
Case 2: Pharmaceutical Formulation
Challenge: Stability issues in generic production
Solution: Optimized bisulfate salt crystallization process
Result: Achieved 24-month shelf life
5. Client Success Stories
Client A: Indian Pharmaceutical Manufacturer
Requirement: Cost-effective API source for generic production
Outcome: Supplied 98.7% pure material at 22% cost reduction
Client B: European Research Consortium
Requirement: High-purity reference standard for clinical trials
Outcome: Delivered 99.3% HPLC-grade material with full documentation
6. Request Customized Solutions
Contact our technical experts for formulation support or bulk inquiries:
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