Tetrabutylurea CAS 4559-86-8

Comprehensive Guide to Tetrabutylurea (CAS 4559-86-8)

Table of Contents

• Product Overview
• Key Parameters & Comparison
• Detailed Applications
• Industry Use Cases
• Client Success Stories
• Request a Quote

Product Overview

Tetrabutylurea (CAS 4559-86-8) is a urea derivative with the molecular formula C₁₇H₃₆N₂O. It is widely used as a solvent, catalyst, or intermediate in pharmaceuticals, agrochemicals, and specialty polymers.

Basic Properties

Parameter Comparison

Detailed Applications

1. Pharmaceutical Synthesis

Acts as a non-polar solvent for Grignard reactions, minimizing side reactions while improving yields up to 15% compared to traditional solvents.

2. Polymer Industry

Enhances flexibility in polyurethane foams as a plasticizer and reduces curing time by 20-30% in epoxy resin formulations.

3. Agrochemicals

Improves solubility of hydrophobic active ingredients in pesticide emulsifiable concentrates (EC formulations).

Industry Use Cases

Case 1: High-Temperature Reaction Solvent

A specialty chemical manufacturer replaced DMF with tetrabutylurea in a Heck coupling reaction at 250°C, achieving 92% yield (vs. 78% with DMF) and reducing purification steps.

Case 2: Lithium Battery Electrolyte Additive

Added 0.5% tetrabutylurea to LiPF₆-based electrolytes, improving battery cycle life by 40% at 60°C through SEI stabilization.

Client Success Stories

Client A: European Pharma Company

Challenge: Low yield (65%) in atorvastatin intermediate synthesis
Solution: Used tetrabutylurea as reaction medium
Result: Yield increased to 83%, reduced catalyst loading by 30%

Client B: US Polymer Manufacturer

Challenge: Brittle polyimide films at high temperatures
Solution: Incorporated 5% tetrabutylurea as plasticizer
Result: Flexibility improved by 50% while maintaining 300°C thermal stability

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