2-Phenoxyaniline (CAS 2688-84-8) Technical Guide
Table of Contents
1. Product Overview & Specifications
Chemical Name: 2-Phenoxyaniline (IUPAC: 2-Aminophenyl phenyl ether)
CAS No.: 2688-84-8
Molecular Formula: C12H11NO
Molecular Weight: 185.22 g/mol
Key Physical Properties
| Parameter | Value |
|---|---|
| Appearance | Brown to gray crystalline powder |
| Melting Point | 45–50°C |
| Boiling Point | 170°C (at 760 mmHg) |
| Flash Point | 113°C |
| LogP | 3.64 |
| Solubility | Slightly soluble in water |
Specification Comparison
| Vendor | Purity | Packaging | Price (USD) |
|---|---|---|---|
| Shanghai Yuanye Bio | ≥99% | 25g/100g | $64–$190 |
| Hubei Coward Chem | ≥99% | 1kg/drum | $23/kg |
| Jingzhou LiZhiyuan | ≥98% | Custom | Contact |
2. Key Applications
- Pharmaceutical Intermediate: Critical component in synthesizing Nimesulide impurity C (EP standard).
- Dye Manufacturing: Key precursor for azo dyes and specialty colorants.
- Agrochemicals: Intermediate for herbicides and fungicides.
- Polymer Additives: Used in UV stabilizers and epoxy curing agents.
3. Usage Guidelines
Storage Recommendations
- Store in airtight containers at 2–8°C
- Protect from light and moisture
- Shelf life: 36 months when properly stored
Safety Protocols
- Use PPE (gloves, goggles, respirator) during handling
- Avoid dust formation – use local exhaust ventilation
- In case of skin contact: Wash thoroughly with soap/water
4. Industry Case Studies
Case 1: Dye Manufacturing Optimization
Challenge: A European dye producer required high-purity intermediates to meet REACH compliance.
Solution: Customized 99.5% pure 2-phenoxyaniline batches with full traceability documentation.
Result: 22% increase in final dye product yield.
Case 2: Pharmaceutical QC Standardization
Challenge: Asian pharma company needed EP-grade reference material for Nimesulide production.
Solution: Supplied GC/MS-validated material with impurity profile ≤0.1%.
Result: Achieved FDA audit compliance with zero observations.
5. Client Success Stories
Shanghai Yuanye Bio-Tech
“Consistent quality and technical support enabled us to develop three new API intermediates using 2-phenoxyaniline as the core building block.”
Hubei Coward Chemical Co.
“The bulk pricing structure allowed us to scale production while maintaining 99%+ purity across 50MT annual output.”
6. Request Customized Solutions
For technical specifications, bulk pricing, or custom synthesis requirements:
+86 15866781826
Available: Mon-Fri 8:00–17:00 (GMT+8)



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