Table of Contents
- Croscarmellose Sodium Overview
- Technical Specifications & Comparative Analysis
- Pharmaceutical Applications & Mechanisms
- Formulation Guidelines & Best Practices
- Industry Implementation Case Studies
- Technical Consultation & Sample Requests
Croscarmellose Sodium (CAS 74811-65-7) Overview
Key Characteristics
| Parameter | Specification |
|---|---|
| Chemical Name | Sodium salt of cross-linked carboxymethylcellulose |
| Appearance | White or off-white free-flowing powder |
| pH (1% solution) | 5.0-7.0 |
| Swelling Capacity | ≥50 ml/10min |
Technical Specifications & Grade Comparison
| Grade | Particle Size (μm) | Moisture Content | Viscosity (mPa·s) |
|---|---|---|---|
| Pharmaceutical Grade | 50-150 | ≤5% | 10-30 |
| Industrial Grade | 150-300 | ≤7% | 30-50 |
Pharmaceutical Formulation Applications
Primary Functions
- Tablet disintegrant in immediate-release formulations
- Dissolution rate enhancer for poorly soluble APIs
- Wetting agent in dry granulation processes
Optimal Usage Parameters
| Formulation Type | Recommended Concentration | Processing Method |
|---|---|---|
| Direct Compression | 2-5% w/w | Dry blending |
| Wet Granulation | 1-3% extragranular | Post-granulation addition |
Industry Implementation Case Studies
Case 1: Novo Pharmaceuticals
Challenge: Improve disintegration time of high-dose ibuprofen tablets
Solution: 4% Croscarmellose Sodium in extragranular phase
Result: Disintegration time reduced from 12min to 2.5min
Case 2: Geneva Pharma
Challenge: Prevent capping in vitamin B complex tablets
Solution: 3% Croscarmellose Sodium with modified drying cycle
Result: Tablet hardness increased by 40% with zero capping
Technical Consultation & Ordering Information
Contact our formulation specialists:
Email: info@vivalr.com
Phone: (86) 15866781826
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