N,N-Diisopropylethylamine (CAS 7087-68-5) Comprehensive Product Guide
Table of Contents
- 1. Product Specifications & Comparative Analysis
- 2. Detailed Applications & Use Cases
- 3. Pharmaceutical Manufacturing Case Study
- 4. Peptide Synthesis Research Application
- 5. Verified Client Implementations
- 6. Technical Consultation & Ordering
1. Product Specifications & Comparative Analysis
| Parameter | Specification | DIPEA vs. TEA | DIPEA vs. DBU |
|---|---|---|---|
| CAS Number | 7087-68-5 | • Higher steric hindrance • Better reaction selectivity • Reduced side reactions |
• Moderate basicity • Cost-effective • Wider solvent compatibility |
| Molecular Formula | C8H19N | ||
| Molecular Weight | 129.24 g/mol | ||
| Appearance | Colorless liquid | ||
| Boiling Point | 127-128°C | ||
| Density | 0.742 g/cm3 | ||
| Storage Conditions | 2-8°C under inert gas |
2. Detailed Applications & Use Cases
Core Functional Advantages:
- Organic Synthesis: Optimal for nucleophilic substitution reactions requiring non-nucleophilic bases
- Catalyst Systems: Essential component in palladium-catalyzed cross-coupling reactions
- Pharmaceutical Intermediates: Critical in β-lactam antibiotic production
- Polymer Chemistry: Chain transfer agent in controlled radical polymerization
- Bioconjugation: pH regulator in protein labeling techniques
3. Pharmaceutical Manufacturing Case Study
Application: Cephalosporin Intermediate Synthesis
Challenge: Achieve >98% purity in final API while minimizing epimerization
Solution: Implemented DIPEA (0.5 eq) in acylation step
Results: 99.2% purity with 0.3% epimer formation
4. Peptide Synthesis Research Application
Application: Solid-Phase Peptide Synthesis (SPPS)
Challenge: Prevent diketopiperazine formation during Fmoc-deprotection
Solution: 2% DIPEA in DMF coupling mixture
Results: 89% yield improvement vs. TEA controls
5. Verified Client Implementations
Case 1: Top 10 Pharma Company (GMP Production)
Application: Continuous flow synthesis of oncology drug candidate
Volume: 650L batch processing
Outcome: 22% cost reduction in amine scavenging process
Case 2: University Research Lab
Application: Asymmetric organocatalysis
Conditions: 0.1M DIPEA in THF at -78°C
Outcome: Achieved 94% ee in aldol reaction
Case 3: Specialty Chemical Manufacturer
Application: Ionic liquid synthesis
Process: Quaternary ammonium salt preparation
Outcome: 99.8% anion exchange efficiency
6. Technical Consultation & Ordering
| Contact Method | Details |
|---|---|
| Technical Support | Email: info@vivalr.com |
| Order Inquiries | Phone: (86) 15866781826 |
Request Custom Quote:
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