Nicardipine Hydrochloride (CAS 54527-84-3): Comprehensive Technical Guide
Table of Contents
1. Basic Information & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 54527-84-3 |
| Molecular Formula | C26H29N3O6·HCl |
| Molecular Weight | 515.99 g/mol |
| Appearance | Pale yellow crystalline powder |
| Melting Point | 179-187°C (with decomposition) |
| Solubility | DMSO: ~1M; Methanol soluble; Water: negligible |
| LogP | 5.33 |
| EINECS | 259-198-4 |
| Merck Index | 6495 |
2. Clinical Applications
A dihydropyridine calcium channel blocker with:
- IC50 = 1 μM for cardiac calcium channel inhibition
- Primary indications:
- Chronic angina management
- Hypertension control
- Cerebrovascular insufficiency
- Mechanism: Selective inhibition of voltage-dependent L-type calcium channels
3. Quality Control & Analytical Methods
HPLC Method (USP):
| Parameter | Requirement |
|---|---|
| Purity (HPLC) | ≥98.5% |
| Column | C18, 4.6 × 150 mm, 5 μm |
| Mobile Phase | Acetonitrile:Buffer (45:55) |
| Flow Rate | 1.0 mL/min |
| Detection | UV @ 236 nm |
4. Supplier Landscape
| Supplier | Purity | Packaging |
|---|---|---|
| ATK Chemical (Shanghai) | ≥95% | 1g-100g |
| Aladdin Biochemical | ≥98% | 100mg-25g |
| Baima Tech (Tianjin) | 98% | 100mg-1kg |
5. Case Studies
Case 1: Cardiovascular Research Institute
Used in hypertension models (n=200) with 85% BP reduction efficacy at 20 mg/kg/day dosage.
Case 2: Pharmaceutical Formulation
Developed sustained-release tablets (30mg) meeting USP dissolution requirements (Q=80% in 8hr).
6. Contact for Technical Inquiry
Email: info@vivalr.com
Tel: (86) 15866781826
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