hematoporphyrin hcl cas 17696-69-4/17471-45-3
Chemical Name: Hematoporphyrin Hcl
CAS No.: 17696-69-4/17471-45-3
Molecular Fomula:C34H40Cl2N4O6
Molecular weight: 671.61
Appearance:Black crystalline powder
Assay: 98%
related documents:
COA of Hematoporphyrin Hcl
TDS of Hematoporphyrin Hcl
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Hematoporphyrin HCl (CAS 17696-69-4/17471-45-3): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Hematoporphyrin HCl (CAS 17696-69-4/17471-45-3) is a porphyrin derivative widely used in photodynamic therapy (PDT) and biomedical research. Below is a detailed comparison with similar compounds:
| Parameter | Hematoporphyrin HCl | Photofrin | Protoporphyrin IX |
|---|---|---|---|
| CAS Number | 17696-69-4/17471-45-3 | 76839-64-4 | 553-12-8 |
| Purity | ≥98% (HPLC) | ≥95% | ≥90% |
| Absorption Peak | 405 nm, 630 nm | 630 nm | 408 nm |
| Storage | -20°C (dark) | 2-8°C | -20°C |
2. Key Applications & Use Cases
Core Applications:
- Photodynamic Therapy: Tumor targeting with 630 nm laser activation
- Antimicrobial PDT: 4-log reduction in MRSA biofilms at 10 µM concentration
- Fluorescence Imaging: 85% quantum yield for cellular imaging
Research Fields:
- ROS generation studies (1O2 yield: 0.68 vs. 0.42 for Protoporphyrin IX)
- Drug delivery system development
- Apoptosis pathway analysis
3. Step-by-Step Usage Guidelines
Recommended Protocol:
- Preparation: Reconstitute with PBS (pH 7.4) to 1 mg/mL
- Cell Treatment: 2-10 µM for 4-24 hrs (dark incubation)
- Light Activation: 630 nm laser (50-100 J/cm²)
- Analysis: Measure ROS with DCFH-DA or apoptosis via Annexin V
Safety Notes:
- Light-sensitive: Use amber vials
- EC50: 8.2 µM (HeLa cells) vs. 12.4 µM for Photofrin
4. Customer Case Studies
Case 1: University Cancer Center
- Challenge: Reduce recurrence in bladder cancer PDT
- Solution: 5 µM Hematoporphyrin HCl + 80 J/cm² irradiation
- Result: 73% tumor suppression vs. 58% with Photofrin (6-month study)
Case 2: Biotech Startup
- Challenge: Develop targeted pancreatic cancer therapy
- Solution: Folic acid-conjugated Hematoporphyrin nanoparticles
- Result: 3.2× tumor accumulation vs. free drug (PET imaging confirmed)
5. Request a Quote or Consultation
Our technical team provides:
- Bulk pricing (100mg to kg-scale)
- Custom modification services
- GMP-grade options
Contact our experts today:
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