d-serine cas 312-84-5

Chemical Name: D-Serine
CAS No.: 312-84-5
Molecular Fomula: C3H7NO3
Molecular weight: 105.09
Appearance: white crystals or crystalline powder
Assay: 98%

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D-Serine (CAS 312-84-5) Technical Guide

1. Product Overview & Specifications

Parameter D-Serine L-Serine (Comparison)
CAS Number 312-84-5 56-45-1
Molecular Formula C3H7NO3 C3H7NO3
Molecular Weight 105.09 g/mol 105.09 g/mol
Melting Point 220°C 228°C
Water Solubility (20°C) 346 g/L 360 g/L
Optical Rotation [α]D20 -14.75° (c=10 in 2N HCl) +14.0° to +15.6°

Key Properties: White crystalline powder, chiral purity >99%, pH 5.5-6.5 (1% aqueous solution). Store at room temperature in airtight containers.

2. Key Applications

Pharmaceuticals

  • NMDA receptor agonist for neurological research
  • Intermediate in lacosamide production
  • Cell culture media component

Industrial Uses

  • Chiral building block for asymmetric synthesis
  • Reference standard in analytical chromatography
  • Biochemical studies of purine/pyrimidine metabolism

3. Usage Guidelines

Handling Precautions

  • Use PPE (gloves, goggles) to prevent eye/skin contact
  • Avoid dust formation – handle in fume hood
  • Incompatible with strong oxidizers

Solution Preparation

  1. Dissolve in deionized water at ≤50°C
  2. Filter through 0.22μm membrane for sterile applications
  3. Adjust pH with HCl/NaOH as required

4. Industry Case Studies

Case 1: Neurological Research (2024)

Client: Shanghai Institute of Neuroscience
Application: 500g D-Serine used in NMDA receptor activation studies, achieving 98.5% purity via HPLC validation.

Case 2: Pharmaceutical Production

Client: Wuhan Hezhong Biotech
Application: 25kg batch utilized in lacosamide intermediate synthesis, yielding 92.3% reaction efficiency.

5. Supplier Comparison

Supplier Purity Packaging Price (USD)
Leyan (Shanghai) 98% 100g $53.00
Nanjing Duly 99% 25g $130.00
Zhengzhou Huawen 99.5% 1kg $1,450.00

6. Contact for Quotation

Request custom formulations or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826

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