lithium acetate dihydrate cas 6108-17-4

Lithium Acetate Dihydrate (CAS 6108-17-4): Overview

Lithium acetate dihydrate (C₂H₃LiO₂·2H₂O) is a hygroscopic crystalline compound widely used in molecular biology, buffer solutions, and organic synthesis. Its CAS registry number is 6108-17-4.

Key Properties

• Molecular Weight: 102.02 g/mol
• Appearance: White crystalline powder
• Solubility: 45.8 g/100 mL (20°C in water)
• pH: 6.5-8.5 (0.1M aqueous solution)

Technical Specifications & Comparative Analysis

Industrial & Research Applications

1. Molecular Biology

Essential component in:

• DNA/RNA precipitation buffers
• Yeast transformation protocols
• PCR buffer formulations

2. Pharmaceutical Manufacturing

• Catalyst in β-lactam antibiotic synthesis
• Excipient in lithium-based therapeutics

3. Chemical Synthesis

• Precursor for lithium-ion battery electrolytes
• Crosslinking agent in polymer chemistry

Operational Guidelines

Standard Preparation (0.5M Solution)

1. Dissolve 51.01 g in 800 mL deionized water
2. Adjust pH to 7.5 with acetic acid
3. Bring final volume to 1 L
4. Filter sterilize (0.22 μm membrane)

Safety Protocols

• Storage: 15-25°C in airtight container
• PPE Requirements: Lab coat, nitrile gloves, eye protection

Documented Use Cases

Case 1: Genomic Research Institute

Application: High-throughput DNA purification
Result: Increased plasmid yield by 40% compared to sodium acetate protocols

Case 2: Battery Material Producer

Application: Lithium-ion electrolyte precursor synthesis
Outcome: Achieved 99.8% purity in pilot-scale production

Case 3: Pharmaceutical Company

Application: Antibiotic crystallization process
Benefit: Reduced crystallization time from 18h to 6h

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