Homopiperazine (CAS 505-66-8): Comprehensive Technical Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | Homopiperazine | Piperazine (CAS 110-85-0) | N-Methylhomopiperazine (CAS 4318-37-0) |
|---|---|---|---|
| Molecular Formula | C5H12N2 | C4H10N2 | C6H14N2 |
| Molecular Weight | 100.16 g/mol | 86.14 g/mol | 114.19 g/mol |
| Melting Point | 38-40°C | 109°C | N/A |
| Boiling Point | 169°C | 146°C | 212°C |
| Purity Grade | ≥98% (GC) | ≥99% | 97% |
Storage Requirements: Maintain in sealed containers at ambient temperature (15-25°C) with ≤60% relative humidity.
2. Industrial Applications
Pharmaceutical Intermediate
- Key component in Fasudil HCl synthesis (vasodilator)
- Precursor for Repaglinide API (antidiabetic medication)
Chemical Synthesis
- Building block for heterocyclic compound development
- Ligand in catalytic systems
3. Operational Guidelines
Handling Protocols
- Use NIOSH-approved respirators when handling powders
- Employ chemical-resistant gloves (Butyl rubber recommended)
Reaction Optimization
- Optimal alkylation conditions: 60-80°C in anhydrous DMF
- Recommended stoichiometric ratio: 1:1.2 (homopiperazine:alkylating agent)
4. Case Studies
Pharmaceutical Manufacturing
Application: Continuous flow synthesis of Fasudil intermediate
Outcome: 23% yield improvement vs batch processing
Agrochemical Development
Application: Fungicide molecular scaffolding
Result: Achieved 98.2% enantiomeric purity
5. Client Success Stories
Jiangmin Taihua Chemical Co., Ltd. (Hubei)
- Annual procurement: 2.8 metric tons
- Application: Antihypertensive API production
- Purity requirement: ≥99.5%
Shanghai Yuanye Bio-Technology
- Research-scale purchases: 50-100g batches
- Usage: Neurological drug discovery
- Special requirement: Chiral separation studies
Technical Consultation & Ordering
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