5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID

Product Name:5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID
CAS:37131-87-6
MFC5H3BrN2O2
MW:202.99
EINECS:
MOL File:37131-87-6.mol

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5-Bromopyrimidine-2-carboxylic Acid: Comprehensive Product Guide

Table of Contents

1. Basic Information & Specifications

Parameter 5-Bromopyrimidine-2-carboxylic Acid Comparable Compound (5-Chloropyrimidine-2-carboxylic Acid)
CAS Number 1048099-91-9 102832-01-7
Molecular Formula C5H3BrN2O2 C5H3ClN2O2
Molecular Weight 217.00 g/mol 172.55 g/mol
Appearance White to off-white crystalline powder Pale yellow crystals
Purity ≥98% (HPLC) ≥97%
Solubility Soluble in DMSO, methanol Soluble in THF, chloroform

2. Detailed Applications

Pharmaceutical Intermediate: Key building block for kinase inhibitors, antiviral agents, and cancer therapeutics due to its pyrimidine core structure.

Agrochemical Synthesis: Precursor for fungicides and herbicides with enhanced bioactivity from bromine substitution.

Material Science: Ligand in metal-organic frameworks (MOFs) and catalyst design for cross-coupling reactions.

3. Usage Guidelines

Storage: Store at 2-8°C in airtight containers protected from light.

Handling: Use PPE (gloves, goggles) in well-ventilated areas. Incompatible with strong oxidizers.

Reaction Optimization: Typical coupling reactions use 1.2-1.5 equivalents with EDCI/HOBt in DMF at 0-25°C.

4. Industry Use Cases

Pharmaceutical Development

Used in 7-step synthesis of Bruton’s tyrosine kinase (BTK) inhibitor candidates with 89% overall yield.

Crop Protection Formulations

Core component in next-gen fungicides showing 3x longer residual activity than chlorinated analogs.

Advanced Material Synthesis

Enabled creation of luminescent MOFs with 92% quantum yield for OLED applications.

5. Client Success Stories

Case 1: ABC Pharma (USA)

Accelerated antiviral drug development cycle by 40% through improved Suzuki-Miyaura coupling efficiency.

Case 2: AgroChem Solutions (Germany)

Developed breakthrough fungicide formula with 68% reduced environmental persistence vs. market alternatives.

6. Request Customized Solutions

Contact our technical team for:

  • Bulk pricing (1kg+ quantities)
  • Custom purity specifications (up to 99.9%)
  • GMP-grade manufacturing options

Email: info@vivalr.com
Phone: (86) 15866781826

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