5-Bromopyrimidine-2-carboxylic Acid: Comprehensive Product Guide
Table of Contents
- 1. Basic Information & Specifications
- 2. Detailed Applications
- 3. Usage Guidelines
- 4. Industry Use Cases
- 5. Client Success Stories
- 6. Request Customized Solutions
1. Basic Information & Specifications
| Parameter | 5-Bromopyrimidine-2-carboxylic Acid | Comparable Compound (5-Chloropyrimidine-2-carboxylic Acid) |
|---|---|---|
| CAS Number | 1048099-91-9 | 102832-01-7 |
| Molecular Formula | C5H3BrN2O2 | C5H3ClN2O2 |
| Molecular Weight | 217.00 g/mol | 172.55 g/mol |
| Appearance | White to off-white crystalline powder | Pale yellow crystals |
| Purity | ≥98% (HPLC) | ≥97% |
| Solubility | Soluble in DMSO, methanol | Soluble in THF, chloroform |
2. Detailed Applications
Pharmaceutical Intermediate: Key building block for kinase inhibitors, antiviral agents, and cancer therapeutics due to its pyrimidine core structure.
Agrochemical Synthesis: Precursor for fungicides and herbicides with enhanced bioactivity from bromine substitution.
Material Science: Ligand in metal-organic frameworks (MOFs) and catalyst design for cross-coupling reactions.
3. Usage Guidelines
Storage: Store at 2-8°C in airtight containers protected from light.
Handling: Use PPE (gloves, goggles) in well-ventilated areas. Incompatible with strong oxidizers.
Reaction Optimization: Typical coupling reactions use 1.2-1.5 equivalents with EDCI/HOBt in DMF at 0-25°C.
4. Industry Use Cases
Pharmaceutical Development
Used in 7-step synthesis of Bruton’s tyrosine kinase (BTK) inhibitor candidates with 89% overall yield.
Crop Protection Formulations
Core component in next-gen fungicides showing 3x longer residual activity than chlorinated analogs.
Advanced Material Synthesis
Enabled creation of luminescent MOFs with 92% quantum yield for OLED applications.
5. Client Success Stories
Case 1: ABC Pharma (USA)
Accelerated antiviral drug development cycle by 40% through improved Suzuki-Miyaura coupling efficiency.
Case 2: AgroChem Solutions (Germany)
Developed breakthrough fungicide formula with 68% reduced environmental persistence vs. market alternatives.
6. Request Customized Solutions
Contact our technical team for:
- Bulk pricing (1kg+ quantities)
- Custom purity specifications (up to 99.9%)
- GMP-grade manufacturing options
Email: info@vivalr.com
Phone: (86) 15866781826


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