Cremophor EL (CAS 61791-12-6): Comprehensive Guide for Pharmaceutical and Industrial Applications
Table of Contents
1. Introduction to Cremophor EL (CAS 61791-12-6)
Cremophor EL, with CAS number 61791-12-6, is a non-ionic surfactant derived from castor oil and ethylene oxide. Widely used in pharmaceuticals, cosmetics, and industrial formulations, it serves as a solubilizer, emulsifier, and stabilizer. Its low toxicity and compatibility with hydrophobic compounds make it a preferred excipient in injectable and oral drug formulations.
2. Key Parameters and Comparative Analysis
| Parameter | Cremophor EL | Tween 80 | PEG-40 Hydrogenated Castor Oil |
|---|---|---|---|
| CAS Number | 61791-12-6 | 9005-65-6 | 61788-85-0 |
| HLB Value | 12-14 | 15 | 13-15 |
| Solubility | Water, ethanol, oils | Water, alcohols | Water, polar solvents |
| Applications | Injectable drugs, oral solutions | Topical emulsions | Cosmetic creams |
Advantages: Superior solubilization capacity for lipophilic drugs, reduced risk of hemolysis compared to alternatives.
3. Detailed Applications of Cremophor EL
Pharmaceuticals
- Solubilizer: Enhances bioavailability of poorly water-soluble APIs (e.g., paclitaxel).
- Emulsifier: Stabilizes lipid-based formulations for IV administration.
Cosmetics
- Improves texture of creams/lotions by homogenizing oil-water phases.
Industrial
- Used in agrochemicals to disperse pesticides.
4. Usage Case Studies
Case 1: Oral Suspension for Antifungal Drug
Challenge: Low solubility of itraconazole (log P = 6.2).
Solution: 10% Cremophor EL increased solubility by 15x, enabling a stable oral suspension.
Case 2: Injectable Vitamin Formulation
Challenge: Precipitation of fat-soluble vitamins during storage.
Solution: 5% Cremophor EL prevented aggregation, achieving 24-month stability.
5. Real Client Success Stories
Client A: PharmaCorp Ltd.
Project: Development of a cyclosporine nanoemulsion.
Result: 30% improvement in bioavailability using Cremophor EL vs. competing surfactants.
Client B: DermaBeauty Inc.
Project: Non-greasy sunscreen with high SPF.
Result: Cremophor EL enabled even distribution of zinc oxide, boosting SPF from 30 to 50.
6. Request a Quote or Sample
Optimize your formulations with premium-grade Cremophor EL (CAS 61791-12-6). Contact our experts for:
- Customized solubility studies
- Bulk pricing (GMP/Kosher certified options available)
- Technical documentation (COA, MSDS)
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