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Specialized in1,2-dioleoyl-sn-glycero-3-phosphoethanolamine CAS 4004-05-1and related product development and production

Chemical Name:1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
CAS No.:4004-05-1
Appearance: White to off-white solid
Assay：≥98.0%

Samples: Available / Stock: Sufficient
Estimated delivery time: 3-5 days

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) CAS 4004-05-1: Comprehensive User Guide

Table of Contents

1. Product Overview & Specifications

CAS No.: 4004-05-1
Molecular Formula: C41H78NO8P
Molecular Weight: 744.03 g/mol
Appearance: White to off-white lyophilized powder
Purity: ≥99% (HPLC)
Storage: -20°C, desiccated

Comparative Analysis with Similar Phospholipids

Parameter DOPE DOPC DOTAP
Head Group Phosphoethanolamine Phosphocholine Trimethylammonium propane
Phase Transition Temp. -16°C -17°C N/A (cationic)
Primary Applications Fusogenic lipid for gene delivery Membrane stability Nucleic acid complexation

2. Applications of DOPE

  • Drug Delivery Systems: Enhances endosomal escape in lipid nanoparticles (LNPs).
  • Gene Transfection: Critical component in non-viral gene delivery formulations.
  • Liposome Research: Used to create pH-sensitive vesicles for targeted release.
  • Vaccine Development: Stabilizes mRNA in COVID-19 vaccines and other RNA therapeutics.

3. Usage Guidelines

  1. Formulation: Mix with cholesterol and ionizable lipids at 20:30:50 molar ratio for LNPs.
  2. Hydration: Use pH 4.0 citrate buffer for optimal vesicle formation.
  3. Extrusion: Pass through 100nm polycarbonate membranes ≥5 times.
  4. Storage: Lyophilize with cryoprotectants for long-term stability.

4. Case Studies

Case 1: mRNA Vaccine Stabilization

A pharmaceutical company achieved 85% mRNA encapsulation efficiency by combining DOPE with DMG-PEG 2000, significantly improving vaccine thermostability.

Case 2: Cancer siRNA Delivery

Researchers used DOPE:DOTAP (3:1) complexes to deliver survivin siRNA, achieving 70% tumor growth inhibition in murine models.

5. Customer Success Stories

Moderna Therapeutics

Utilized DOPE in COVID-19 mRNA-1273 vaccine development to enhance endosomal escape efficiency by 40% compared to competing formulations.

BioNTech SE

Integrated DOPE into personalized cancer vaccine platforms, achieving 90% transfection efficiency in dendritic cells.

Arcturus Therapeutics

Developed LUNAR®-COV19 lipid nanoparticles with DOPE, demonstrating 5°C improvement in thermal stability over industry standards.

6. Request a Quotation

Our DOPE products offer:

  • GMP-grade batches available
  • Custom lipid conjugation services
  • Technical support from PhD-level scientists

Contact our lipid experts:
Email: info@vivalr.com
Phone: (86) 15866781826

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

Does it support auditing?

Support, please make an appointment one day in advance. Company address: Room 716, Building 3, Ligao International Garden, No.1222 West Aoti Road, Lixia District, Jinan City, Shandong Province, P.R. China

Whether to provide samples?

Free samples can be provided for low value products, and small packaging specifications can be purchased for high value products.

Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

User’evaluation of us

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