1. Product Overview & Specifications

CAS No.: 4004-05-1
Molecular Formula: C₄₁H₇₈NO₈P
Molecular Weight: 744.03 g/mol
Appearance: White to off-white lyophilized powder
Purity: ≥99% (HPLC)
Storage: -20°C, desiccated

Comparative Analysis with Similar Phospholipids

2. Applications of DOPE

• Drug Delivery Systems: Enhances endosomal escape in lipid nanoparticles (LNPs).
• Gene Transfection: Critical component in non-viral gene delivery formulations.
• Liposome Research: Used to create pH-sensitive vesicles for targeted release.
• Vaccine Development: Stabilizes mRNA in COVID-19 vaccines and other RNA therapeutics.

3. Usage Guidelines

1. Formulation: Mix with cholesterol and ionizable lipids at 20:30:50 molar ratio for LNPs.
2. Hydration: Use pH 4.0 citrate buffer for optimal vesicle formation.
3. Extrusion: Pass through 100nm polycarbonate membranes ≥5 times.
4. Storage: Lyophilize with cryoprotectants for long-term stability.

4. Case Studies

Case 1: mRNA Vaccine Stabilization

A pharmaceutical company achieved 85% mRNA encapsulation efficiency by combining DOPE with DMG-PEG 2000, significantly improving vaccine thermostability.

Case 2: Cancer siRNA Delivery

Researchers used DOPE:DOTAP (3:1) complexes to deliver survivin siRNA, achieving 70% tumor growth inhibition in murine models.

5. Customer Success Stories

Moderna Therapeutics

Utilized DOPE in COVID-19 mRNA-1273 vaccine development to enhance endosomal escape efficiency by 40% compared to competing formulations.

BioNTech SE

Integrated DOPE into personalized cancer vaccine platforms, achieving 90% transfection efficiency in dendritic cells.

Arcturus Therapeutics

Developed LUNAR®-COV19 lipid nanoparticles with DOPE, demonstrating 5°C improvement in thermal stability over industry standards.

6. Request a Quotation

Our DOPE products offer:

• GMP-grade batches available
• Custom lipid conjugation services
• Technical support from PhD-level scientists

Contact our lipid experts:
Email: info@vivalr.com
Phone: (86) 15866781826