n-iodosuccinimide cas 516-12-1

N-Iodosuccinimide (CAS 516-12-1) User Guide

1. Product Information & Specifications

2. Key Applications

• Organic Synthesis: Selective iodination agent for alkenes, alkynes, and aromatic compounds
• Pharmaceutical Intermediates: Critical in synthesizing anti-thyroid drugs and radiocontrast agents
• Polymer Chemistry: Modifies polymer chains for UV-resistant materials
• Research Reagent: Used in radical-initiated reactions and heterocycle formation

3. Usage Cases

Case 1: Iodination of Steroidal Compounds

Procedure: Dissolve 1.2 eq N-iodosuccinimide in anhydrous DCM under nitrogen. Add 1 eq substrate dropwise at 0°C. Monitor reaction via TLC (Hexane:EA = 3:1). Yield: 82-89%.

Case 2: Synthesis of Aryl Iodides

Optimized Conditions: 1.5 eq NIS, BF3·Et2O catalyst in acetonitrile at 60°C for 6 hrs. Achieved 94% regioselectivity.

4. Client Success Stories

Client 1: Top 10 Pharma Company (Germany)

• Challenge: Required high-purity iodinated intermediates for Phase III clinical trials
• Solution: Customized particle size distribution (50-100 μm)
• Outcome: Reduced purification steps by 40%, accelerated FDA submission

Client 2: Specialty Chemical Manufacturer (USA)

• Challenge: Batch inconsistency in iodination reactions
• Solution: Technical grade NIS with stabilized succinimide content
• Outcome: Achieved 99.2% batch-to-batch reproducibility

5. Request a Quote

Contact our technical team for bulk pricing, COA, or custom synthesis requirements:

• Email: info@vivalr.com
• Tel: (86) 15866781826

Next Steps:

1. Share your target compound structure
2. Receive customized iodination protocol within 24hrs
3. Request free 5g sample for method validation