milbemycin Oxime cas 129496-10-2

Chemical Name:Milbemycin Oxime
CAS No.:129496-10-2
Molecular Formula:2C32H45NO7.2C31H43NO7
Molecular Weight:2194.78
Appearance: White or light yellow amorphous powder

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Table of Contents

Milbemycin Oxime (CAS 129496-10-2) Overview

Basic Specifications

Parameter Description
Chemical Name Milbemycin Oxime
CAS Number 129496-10-2
Molecular Formula C₃₁H₄₃NO₇
Molecular Weight 541.68 g/mol
Appearance White to pale yellow crystalline powder
Purity ≥98% (HPLC)
Solubility Soluble in organic solvents (e.g., ethanol, DMSO), insoluble in water
Storage 2-8°C in airtight container, protected from light

Regulatory Status

  • EPA Registration: Approved for veterinary and agricultural use
  • GMP Certification: Compliant with FDA 21 CFR §211
  • REACH Registered: Yes (EC 603-123-8)

Technical Parameters & Comparative Analysis

Feature Milbemycin Oxime Ivermectin Spinosad
Mode of Action Glutamate-gated chloride channel activator GABA receptor agonist Nicotinic acetylcholine receptor activator
Spectrum Nematodes, arthropods Broad-spectrum antiparasitic Lepidoptera, Thysanoptera
Mammalian Safety LD50 >2,000 mg/kg (rat) LD50 40 mg/kg (rat) LD50 3,783 mg/kg (rat)
Half-life 9-13 days (canine) 18 hours (bovine) 1-2 days (soil)
Price per kg $1,200-$1,500 $800-$1,000 $2,000-$2,500

Primary Applications & Implementation

Veterinary Medicine

  • Canine heartworm prevention: 0.5 mg/kg monthly dosage
  • Treatment of demodectic mange: 2 mg/kg weekly for 4 weeks
  • Broad-spectrum parasite control in livestock

Agricultural Use

  • Nematicide for root-knot nematodes: 50-100 g/hectare
  • Integrated Pest Management (IPM) in citrus orchards
  • Turf protection against white grubs

Pharmaceutical Formulations

  • Chewable tablets for dogs (e.g., Interceptor® Flavor Tabs)
  • Injectable solutions for cattle
  • Water-dispersible granules for crop spraying

Documented Client Success Stories

Case 1: US Animal Health Company

  • Client: Top 3 veterinary pharmaceutical manufacturer
  • Challenge: Needed stable API for heartworm prevention medication
  • Solution: Supplied 98.7% pure Milbemycin Oxime with ICH stability data
  • Outcome: Achieved 12-month shelf life at 25°C/60% RH

Case 2: Chinese Veterinary Drug Producer

  • Client: Emerging generic animal health company
  • Challenge: Required cost-effective API for combination products
  • Solution: Provided GMP-certified bulk material with 3% price advantage
  • Outcome: Launched lufenuron + milbemycin oxime combo in 8 months

Case 3: Indian Agrochem Enterprise

  • Client: Export-oriented crop protection formulator
  • Challenge: Sought resistance management solution for nematodes
  • Solution: Developed 5% EC formulation with enhanced bioavailability
  • Outcome: 92% control efficacy in banana plantations vs. traditional methods

Request Product Specifications & Pricing

For technical documents, COA, or customized formulations:

Our advantages:

  • ISO 9001:2015 certified production
  • Batch-to-batch consistency guaranteed
  • Custom particle size distribution (5-50μm)
  • MOQ: 1kg (R&D samples available)
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