Boc-O-benzyl-L-threonine (CAS 15260-10-3) User Guide

1. Product Overview & Specifications

Boc-O-benzyl-L-threonine (CAS 15260-10-3) is a protected amino acid derivative widely used in peptide synthesis. Key parameters:

2. Key Applications

2.1 Peptide Synthesis

Enables selective protection of threonine hydroxyl groups during SPPS (Solid-Phase Peptide Synthesis).

2.2 Pharmaceutical Intermediate

Critical for constructing glycopeptide antibiotics and targeted cancer therapies.

3. Usage Guidelines

3.1 Deprotection Protocol

Recommended cleavage: 30% TFA in DCM for 2hr at 0°C.

3.2 Compatibility

Stable with Fmoc/t-Bu strategies. Avoid strong nucleophiles.

4. Case Studies

4.1 Vaccine Adjuvant Development

Used in synthesizing TLR-2 agonist peptides for COVID-19 vaccine candidates.

4.2 Antibiotic Modification

Key building block in vancomycin analog synthesis (Patent US20210071121A1).

5. Client Success Stories

5.1 PharmaTech Solutions

Challenge: Needed scale-up to 50kg batches for Phase III trials
Result: Achieved 99.2% purity with our GMP-grade material

5.2 BioSynth Laboratories

Challenge: Required chiral purity for CNS drug development
Result: Maintained >99% ee through 15-step synthesis

6. Contact for Technical Support

Email: info@vivalr.com
Tel: (86) 15866781826

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