boc-O-(2-bromo-cbz)-l-tyrosine cas 47689-67-8

Chemical Name:Boc-O-(2-bromo-Cbz)-L-Tyrosine
CAS No.:47689-67-8Molecular Fomula:C22H24BrNO7
Molecular weight: 494.33
Appearance:White powder
Assay: 98.5%min

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Boc-O-(2-Bromo-Cbz)-L-Tyrosine CAS 47689-67-8: Ultimate Guide

1. Product Overview & Specifications
2. Key Applications & Industrial Uses
3. Operational Best Practices
4. Comparative Analysis with Alternatives
5. Verified Customer Case Studies
6. Request Customized Quotation

1. Product Overview & Specifications

Parameter	Specification
CAS Number	47689-67-8
Molecular Formula	C₂₃H₂₅BrN₂O₆
Molecular Weight	523.36 g/mol
Purity	≥98% (HPLC)
Storage Conditions	2-8°C in dry environment
Protection Groups	Boc (tert-butoxycarbonyl), Cbz (Carbobenzyloxy)

2. Key Applications & Industrial Uses

Pharmaceutical Intermediate

Critical building block for kinase inhibitor development in oncology therapeutics.

Peptide Synthesis

Enables selective deprotection in Fmoc-based solid-phase peptide synthesis (SPPS).

Chemical Biology Research

Used in post-translational modification studies of tyrosine residues.

3. Operational Best Practices

Handling Protocol

Always use anhydrous conditions with molecular sieves for moisture-sensitive reactions.

Deprotection Methods

Boc removal: 30% TFA in DCM (0-5°C); Cbz cleavage: H₂/Pd-C in ethanol.

4. Comparative Analysis with Alternatives

Feature	Boc-O-(2-Bromo-Cbz)-L-Tyrosine	Standard Fmoc-Tyr(tBu)-OH
Orthogonal Protection	Dual Boc/Cbz groups	Single Fmoc group
Bromine Functionality	Enables Suzuki couplings	Not available
Acid Sensitivity	Stable up to pH 2.5	Degrades below pH 4

5. Verified Customer Case Studies

Case 1: Oncotherapeutics Development (2024)

Client: Top 10 Global Pharma Company
Application: Synthesized BTK inhibitor candidate RC-1128
Result: Achieved 92% yield in key coupling step

Case 2: University Research Project

Client: MIT Chemical Biology Lab
Application: Created fluorescent tyrosine analogs for protein tracking
Result: Published in Nature Chemical Biology (2023)

6. Request Customized Quotation

For bulk pricing (1kg+ orders) or GMP-grade material:
Email: info@vivalr.com
Phone: (86) 15866781826

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boc-O-(2-bromo-cbz)-l-tyrosine cas 47689-67-8

Boc-O-(2-Bromo-Cbz)-L-Tyrosine CAS 47689-67-8: Ultimate Guide