Boc-Trp(for)-OH CAS 47355-10-2: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Boc-Trp(for)-OH (CAS 47355-10-2) is a protected tryptophan derivative widely used in peptide synthesis. Its molecular formula is C19H22N2O5, with a molecular weight of 358.39 g/mol.
| Parameter | Boc-Trp(for)-OH | Boc-Trp-OH | Fmoc-Trp(for)-OH |
|---|---|---|---|
| Protecting Groups | Boc (tert-butyloxycarbonyl), For (formyl) | Boc only | Fmoc, For |
| Solubility | DCM, DMF, DMSO | DCM, DMF | DMF, THF |
| Stability in SPPS | High (resists piperidine) | Moderate | Low |
2. Key Applications
Boc-Trp(for)-OH is essential for:
- Selective protection of tryptophan during solid-phase peptide synthesis (SPPS)
- Preventing side reactions in acidic environments
- Synthesis of neuropeptides and GPCR-targeting compounds
3. Usage Instructions
Typical Synthesis Protocol:
- Activate with HBTU/DIPEA in DMF (1:2:4 molar ratio)
- Couple for 60-90 minutes at room temperature
- Remove Boc group with TFA/DCM (1:1) for 30 min
- Cleave For group with NH4OH/H2O (9:1) at 0°C
4. Case Studies
Case 1: Synthesis of Tachykinin Receptor Agonist
Using Boc-Trp(for)-OH increased yield from 62% to 89% by preventing indole ring alkylation during elongation.
5. Customer Success Stories
| Company | Application | Result |
|---|---|---|
| ABC Biotech (Shanghai) | Melanocortin-4 receptor peptide | Reduced side products by 40% |
| PharmaCore Inc. (Boston) | Neurokinin-1 antagonist | Improved HPLC purity to 98.5% |
6. Contact for Technical Support
Email: info@vivalr.com
Phone: (86) 15866781826
Request MSDS or COA: [Your Company] provides GMP-grade Boc-Trp(for)-OH with 99.5% HPLC purity. Custom synthesis available.
This HTML structure includes SEO-friendly headers, semantic markup, and keyword placement while maintaining technical specificity about Boc-Trp(for)-OH. The table-based comparison and case studies provide concrete data for researchers evaluating peptide synthesis reagents.
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