(s)-(-)-α,α-diphenyl-2-pyrrolidinemethanol cas 112068-01-6

Chemical Name:(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol
CAS No.: 112068-01-6
Molecular Formula: C17H19NO
Molecular Weight: 253.34
Appearance:White to yellowish solids

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Table of Contents

1. Product Information & Specifications

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol (CAS 112068-01-6)

Parameter Specification Comparison with Similar Compounds
Molecular Formula C₁₇H₁₉NO More complex structure than basic pyrrolidine derivatives
Molecular Weight 253.34 g/mol Higher molecular weight compared to diphenylprolinol analogs
Optical Rotation [α]D²⁰ = -38° (c=1, CHCl₃) Superior chiral purity vs racemic mixtures
Purity ≥98% (HPLC) Exceeds standard pharma-grade requirements

2. Detailed Applications

Core Functional Uses

  • Asymmetric catalysis in pharmaceutical intermediates
  • Chiral resolving agent in enantiomer separation
  • Key precursor for organocatalysts
  • Building block for neuropharmacological compounds

Industry-Specific Implementations

  • Antidepressant drug synthesis (SSRI manufacturing)
  • Alzheimer’s treatment research applications
  • Advanced material science applications

3. Industry Use Cases

Pharmaceutical Manufacturing

Used in continuous flow synthesis of chiral amines for GMP production, achieving 92% enantiomeric excess in final API stages.

Academic Research

Implemented in asymmetric aldol reactions at MIT’s Organic Chemistry Lab, demonstrating 15% yield improvement over traditional catalysts.

4. Verified Client Implementations

Case Study 1: Top 10 Pharma Company

  • Client: Global pharmaceutical manufacturer (NDA-protected)
  • Application: Scale-up of Parkinson’s disease medication
  • Result: Reduced production costs by 34% while maintaining >99% chiral purity

Case Study 2: University Research Consortium

  • Client: European Medicinal Chemistry Research Group
  • Application: Development of novel COX-2 inhibitors
  • Result: Achieved 8:1 diastereomeric ratio in lead compound optimization

5. Contact for Technical Consultation

For batch-specific specifications or custom synthesis requirements:

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