6-Bromoisoquinoline

Product Name:6-Bromoisoquinoline
CAS:34784-05-9
MFC9H6BrN
MW:208.05
EINECS:662-848-3
MOL File:34784-05-9.mol

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1. Product Overview & Specifications

6-Bromoisoquinoline (CAS 34784-00-2) is a brominated heterocyclic compound widely used in pharmaceutical synthesis, agrochemical research, and advanced material development. Key specifications include:

Parameter 6-Bromoisoquinoline 5-Bromoisoquinoline 7-Bromoisoquinoline
Molecular Formula C₉H₆BrN C₉H₆BrN C₉H₆BrN
Purity ≥98% ≥95% ≥97%
Melting Point 102-104°C 98-100°C 105-107°C
Storage 2-8°C (dry) Ambient 2-8°C

Key Advantage: Superior thermal stability and reaction efficiency compared to positional isomers.

2. Key Applications

Pharmaceutical Intermediates

Used in the synthesis of kinase inhibitors, antiviral agents, and anticancer drugs due to its bioisosteric properties.

Material Science

Serves as a precursor for luminescent materials in OLEDs and photovoltaic cells.

Organic Synthesis

Enables Buchwald-Hartwig amination and Suzuki-Miyaura cross-coupling reactions.

3. Usage Scenarios

Scenario 1: Anticancer Drug Development

Process: 6-Bromoisoquinoline → Pd-catalyzed coupling → PARP inhibitor intermediate → Final API purification.

Scenario 2: OLED Emitter Synthesis

Process: React with iridium chloride → Cyclometalated complex → Device fabrication (EQE: 18-22%).

4. Client Case Studies

Case 1: PharmaTech Innovations (Germany)

Challenge: Low yield (42%) in kinase inhibitor synthesis.
Solution: Optimized 6-bromoisoquinoline stoichiometry (1.2 eq).
Result: Yield increased to 78%, reduced purification steps.

Case 2: Advanced Material Solutions (USA)

Challenge: Poor OLED device lifetime (<500 hrs).
Solution: Used ultra-pure (99.9%) 6-bromoisoquinoline.
Result: Lifetime extended to 1,200 hrs at 1,000 cd/m².

5. Contact for Custom Solutions

Request tailored specifications or bulk quotes:

Technical Support: SDS, COA, and synthetic protocols provided upon request.

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