2-Chloro-3-pyridinecarboxaldehyde: Comprehensive Technical Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 36404-88-3 |
| Molecular Formula | C6H4ClNO |
| Molecular Weight | 141.56 g/mol |
| Melting Point | 50-54°C (lit.) |
| Flash Point | >230°C |
| Storage | Room temperature |
2. Key Applications
This heterocyclic compound serves as a critical intermediate in:
- Synthesis of 5-azaindoles via Hemetsberger-Knittel reaction
- Pharmaceutical intermediates for kinase inhibitors
- Agrochemical research for novel pesticide development
- Coordination chemistry for ligand synthesis
3. Usage Guidelines
Handling Precautions
- Use PPE (gloves, goggles, lab coat) in well-ventilated areas
- Avoid contact with strong oxidizers
- Store in airtight containers away from moisture
Reaction Optimization
- Optimal temperature range: 60-80°C
- Recommended solvent systems: DMF, THF, or DCM
- Typical reaction time: 4-12 hours
4. Industry Case Studies
Case Study 1: Pharmaceutical API Development
Client: Top-tier European pharma company
Application: Key intermediate in JAK inhibitor synthesis
Outcome: Achieved 92% yield in scale-up production
Case Study 2: Agrochemical Innovation
Client: Asia-Pacific agrochemical leader
Application: Novel neonicotinoid derivative synthesis
Outcome: Reduced production costs by 37% vs traditional routes
5. Inquiry & Technical Support
For bulk orders or technical consultation:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Request SDS documentation or custom synthesis options.


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