2-Chloro-3-pyridinecarboxaldehyde

Product Name:2-Chloro-3-pyridinecarboxaldehyde
CAS:36404-88-3
MFC6H4ClNO
MW:141.56
EINECS:
MOL File:36404-88-3.mol

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2-Chloro-3-pyridinecarboxaldehyde: Comprehensive Technical Guide

1. Product Overview & Specifications

Parameter Specification
CAS Number 36404-88-3
Molecular Formula C6H4ClNO
Molecular Weight 141.56 g/mol
Melting Point 50-54°C (lit.)
Flash Point >230°C
Storage Room temperature

2. Key Applications

This heterocyclic compound serves as a critical intermediate in:

  • Synthesis of 5-azaindoles via Hemetsberger-Knittel reaction
  • Pharmaceutical intermediates for kinase inhibitors
  • Agrochemical research for novel pesticide development
  • Coordination chemistry for ligand synthesis

3. Usage Guidelines

Handling Precautions

  • Use PPE (gloves, goggles, lab coat) in well-ventilated areas
  • Avoid contact with strong oxidizers
  • Store in airtight containers away from moisture

Reaction Optimization

  • Optimal temperature range: 60-80°C
  • Recommended solvent systems: DMF, THF, or DCM
  • Typical reaction time: 4-12 hours

4. Industry Case Studies

Case Study 1: Pharmaceutical API Development

Client: Top-tier European pharma company
Application: Key intermediate in JAK inhibitor synthesis
Outcome: Achieved 92% yield in scale-up production

Case Study 2: Agrochemical Innovation

Client: Asia-Pacific agrochemical leader
Application: Novel neonicotinoid derivative synthesis
Outcome: Reduced production costs by 37% vs traditional routes

5. Inquiry & Technical Support

For bulk orders or technical consultation:

Request SDS documentation or custom synthesis options.

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