Comprehensive Guide to 3-Bromoquinoline: Properties, Applications, and Industry Insights
Table of Contents
1. Product Overview & Specifications
| Parameter | 3-Bromoquinoline | 2-Bromoquinoline | 4-Bromoquinoline |
|---|---|---|---|
| CAS Number | 5332-25-2 | 2005-45-8 | 4918-97-4 |
| Molecular Formula | C9H6BrN | C9H6BrN | C9H6BrN |
| Purity (HPLC) | ≥99.5% | ≥98% | ≥99% |
| Melting Point | 54-56°C | 49-51°C | 62-64°C |
Advantages: Superior thermal stability, higher reactivity in Suzuki couplings, and optimal solubility in THF/DMF compared to positional isomers.
2. Key Applications of 3-Bromoquinoline
Pharmaceutical Intermediates
Critical for synthesizing kinase inhibitors (e.g., EGFR inhibitors) and antimicrobial agents. Enables precise bromine positioning for targeted drug design.
Organic Electronics
Used in OLED electron-transport layers and perovskite solar cell additives. Enhances device efficiency by 15-20% in recent trials.
Agrochemical Development
Key precursor for novel fungicides with lower environmental persistence than traditional chlorinated compounds.
3. Usage Scenarios by Industry
Pharmaceutical Research
Problem: Low-yield cross-coupling in anti-cancer compound synthesis
Solution: 3-Bromo substitution improves reaction yield from 68% to 92% in palladium-catalyzed reactions
Material Science
Challenge: OLED layer crystallization issues
Application: 3-Bromoquinoline derivatives reduce crystallization tendency by 40% while maintaining conductivity
4. Verified Client Success Stories
Case 1: PharmaGen Therapeutics
Project: Development of third-generation BTK inhibitor
Results: Achieved 94% purity in final API using our 3-Bromoquinoline (Lot# BGQ-2203), accelerating FDA submission by 5 months
Case 2: AgroSolutions Ltd.
Challenge: Developing low-toxicity rice blast fungicide
Outcome: 3-Bromoquinoline derivative showed 98% efficacy at half the concentration of market alternatives
5. Request Customized Solutions
Contact our technical team for batch-specific COA, custom synthesis, or application support:
Email: info@vivalr.com
Tel: (86) 15866781826
Response guaranteed within 4 working hours for all technical inquiries.


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