5-Chloro-7-azaindole: Comprehensive User Guide

1. Product Overview & Specifications

Chemical Profile

5-Chloro-7-azaindole (CAS 948566-48-1) is a heterocyclic compound with molecular formula C₇H₅ClN₂ and molecular weight 152.58 g/mol. This pale yellow crystalline powder features dual nitrogen atoms in its bicyclic structure, offering unique reactivity for pharmaceutical and material science applications.

Technical Specifications

2. Key Applications

Pharmaceutical Intermediates

Widely used in synthesizing kinase inhibitors, particularly for:

• JAK/STAT pathway modulators
• Oncology therapeutics
• Anti-inflammatory compounds

Material Science

• OLED precursor for blue-light emitters
• Coordination complexes for catalysis

3. Usage Guidelines

Storage Recommendations

Reaction Optimization

For Buchwald-Hartwig amination:

1. Use 1.2-1.5 molar equivalents
2. Maintain reaction temperature at 80-100°C
3. Employ Pd(dba)₂/Xantphos catalyst system

4. Case Studies

Case 1: Anticancer Drug Development

Challenge: Improve selectivity of kinase inhibitor TAK-285
Solution: Structural modification using 5-Chloro-7-azaindole core
Outcome: 3.2x IC50 improvement vs. wild-type receptors

5. Client Success Stories

PharmaTech Solutions (Germany)

Project: Development of JAK3 inhibitor for autoimmune diseases
Results: Achieved 92% yield in key coupling reaction
Testimonial: “The exceptional purity reduced purification steps by 40%”

NanoMaterials Inc. (USA)

Application: OLED emitter matrix for flexible displays
Performance: 18% efficiency improvement vs. standard indole derivatives

6. Contact for Custom Solutions

Our technical team specializes in:

• Bulk quantities (100g-50kg)
• Custom derivatization services
• GMP-grade manufacturing

Contact our experts:
Email: info@vivalr.com
Phone: (86) 15866781826