4-Chloropyridine-2-carboxylic acid

4-Chloropyridine-2-carboxylic Acid: Comprehensive Guide

Table of Contents

• Product Overview & Specifications
• Detailed Applications
• Usage Guidelines
• Industry Case Studies
• Client Success Stories
• Contact for Technical Support

Product Overview & Specifications

4-Chloropyridine-2-carboxylic Acid (CAS 102379-46-6) is a halogenated pyridine derivative with molecular formula C₆H₄ClNO₂. Key parameters:

Detailed Applications

Pharmaceutical Intermediate

Critical for synthesizing kinase inhibitors in oncology drugs like Lorlatinib (ALK/ROS1 inhibitor). Enables precise chloro-substitution for target binding.

Agrochemical Synthesis

Used in neonicotinoid insecticide precursors, providing enhanced pest resistance management through pyridine ring modification.

Usage Guidelines

Reaction Optimization

Recommended 0.5-2.0 molar equivalents in Suzuki-Miyaura couplings. Maintain inert atmosphere (N₂/Ar) for optimal yields.

Safety Protocols

Always use PPE including chemical goggles and nitrile gloves. Store at 2-8°C under dry conditions (max. 40% RH).

Industry Case Studies

Antiviral Drug Development

Used by a Swiss pharma company to create broad-spectrum antiviral compounds targeting RNA viruses. Achieved 78% yield improvement over traditional routes.

Advanced Material Synthesis

Enabled a Japanese electronics firm to develop thermally stable organic semiconductors (T_g > 200°C) for flexible displays.

Client Success Stories

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