Product Overview
Basic Specifications
| Parameter | Value |
|---|---|
| CAS No. | 57489-77-7 |
| Molecular Formula | C₆H₃Cl₂N₃ |
| Molecular Weight | 188.01 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥97% (HPLC) |
| Storage | Room temperature (3 years), -20°C for prolonged stability |
Comparative Analysis
| Feature | 5,7-Dichloropyrazolo[1,5-a]pyrimidine | Analogous Compounds |
|---|---|---|
| Biological Target | PDE10A (Ki=24 μM) | Varies by derivative |
| Thermal Stability | Stable up to 150°C | Lower thermal resistance |
| Pharmaceutical Relevance | Schizophrenia research | Limited applications |
Applications
Pharmaceutical Intermediates
Widely utilized in synthesizing PDE10A inhibitors for CNS disorder therapeutics.
Research Applications
- Key precursor in developing antipsychotic agents (e.g., Bioorg Med Chem Lett, 2016)
- Intermediate for kinase inhibitor development
Case Studies
Academic Research
Used in fragment-based drug discovery at University of Cambridge (2019-2024) to optimize blood-brain barrier penetration.
Industrial Synthesis
Shanghai JZ Biochemical Co. employs batch-scale production (≥50 kg/mo) for global pharma partners.
Client Implementations
Case 1: Neuropharma Solutions
- Application: PDE10A inhibitor lead optimization
- Scale: 10 kg annual consumption
- Outcome: Advanced to preclinical trials (2024)
Case 2: Hubei XMT Chemicals
- Application: Custom intermediate synthesis
- Scale: 200 kg bulk order (2024 Q4)
- Purity: 99.2% achieved
Technical Inquiry
Request custom synthesis or bulk pricing:
Email: info@vivalr.com
Phone: (86) 15866781826
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